Abstract:Understanding how multicopper oxidases (MCOs) efficiently and selectively reduce oxygen in the trinuclear copper cluster (TNC) is of great importance. Previously it was reported that when the T2-site is removed from the TNC, all O2 binding activity at the dinuclear T3-site is lost. Computational studies attribute this loss of activity to the flexibility of the protein active site, where the T3-copper centers move apart to minimize electrostatic repulsions. To address the question if and how a more constrained … Show more
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