Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

Lo, Emily Kwun Kwan; Wang, Xiuwan; Lee, Pui-Kei; Wong, Ho-Ching; Lee, Jetty Chung‐Yung; Gómez-Gallego, Carlos; Zhao, Danyue; El‐Nezami, Hani; Li, Jun

doi:10.1016/j.csbj.2023.02.048

Cited by 8 publications

(2 citation statements)

References 46 publications

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“…[67] Lactobacillus, Odoribacter, GCA−900066575, Ruminococcus_1, Rikenella, and Ruminococaceae_UCG-014 were associated with acetate, propionate, and butyrate productions and promoted intestinal host immunity. [68][69][70][71][72] These SCFAs, apart from physiological functions and energy sources, also exert anti-inflammatory effects on the intestinal mucosa [73] by activating the PPAR𝛾 pathway in immune cells. Butyrate, acetate, and propionate indicated a potential role in the PPAR𝛾 activation [74] and NF-kB p65 inhibition [75] that regulated the intestinal epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

Madjirebaye,

Peng,

Mueed

et al. 2024

Molecular Nutrition Food Res

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ScopeLactic acid bacteria with probiotic functions and their fermentation products play a role in regulating ulcerative colitis (UC). This study investigates the potential role of fermented soymilk (FSM4) rich in isoflavones on DSS‐induced UC.Methods and ResultsMice received 3% DSS and are supplemented daily once for 1 week by NFSM and FSM4. DSS usually causes intestinal inflammation and alters the gut microbiota. FSM4 intervention improves the UC‐related inflammation and gut microbiota alteration. It considerably decreases pro‐inflammatories such as TNF‐α, IL‐1β, and IL‐6 in serum and COX‐2 and MPO in colon tissues and pathogenic bacteria (Escherichia‐Shigella). This facilitates gut‐healthy bacteria growth. These healthy bacteria negatively correlat with pro‐inflammatory factors but positively associated with acetic acid, butyric acid, and propionic acid, which may act for PPAR‐γ pathway activating and NF‐κB p65 pathway inhibiting, lowering the risk of UC. Overall, FSM4 might alleviate UC and significantly reverse the dysbiosis of gut microbiota via the PPAR‐γ activation. It could be a good alternative for developing functional food to protect against UC.ConclusionFSM4 attenuates intestinal inflammation and modulates the SCFA‐producing bacteria growth, which enable the PPAR‐γ activation to alleviate the UC target, which could be a dietary intervention strategy for gut health.

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Section: Discussionmentioning

confidence: 99%

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

Madjirebaye,

Peng,

Mueed

et al. 2024

Molecular Nutrition Food Res

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“…The biological function of Tuzzerella remains unknown, including how it may help in the treatment of NASH. In a multi‐omics study of colorectal cancer, Tuzzerel was also the microbiol genus that was most associated with other genes and metabolites, including a negative association with serum uric acid levels and the expression of BEST4 and DGKB genes (Lo et al, 2023 ). In our correlation analysis, we found a high correlation between up to 14 species of host serum metabolites and intestinal abundance of the Tuzzerella genus.…”

Section: Discussionmentioning

confidence: 99%

Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet‐fed mice

Cao,

Yue,

Cheng

et al. 2023

Food Science & Nutrition

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Non‐alcoholic steatohepatitis (NASH) is a severe inflammatory phase of the non‐alcoholic fatty liver disease (NAFLD) spectrum and can progress to advanced stages of NAFLD if left untreated. This study uses multi‐omics data to elucidate the underlying mechanism of naringenin's reported benefit in alleviating (NASH). Male mice were fed a NASH‐inducing (methionine‐choline‐deficient) MCD diet with or without naringenin supplementation for 6 weeks. Naringenin prevented NASH‐induced histopathological liver damage and reversed the abnormal levels of hepatic triglyceride (TG)/total cholesterol (TC), serum TG/TC, serum alanine aminotransferase/aspartate transaminase, and hepatic malondialdehyde and glutathione. Importantly, naringenin intervention significantly modulated the relative abundance of gut microbiota and the host metabolomic profile. We detected more than 700 metabolites in the serum and found that the gut genus levels of Anaeroplasma and the [Eubacterium] nodatum group were closely associated with xanthine, 2‐picoline, and securinine, respectively. Tuzzerella alterations showed the highest number of associations with host endogenous metabolites such as FAHFA (8:0/10:0), FFA (20:2), carnitine C8:1, tridecanedioic acid, securinine, acetylvaline, DL‐O‐tyrosine, and Phe‐Asn. This study indicates that the interplay between host serum metabolites and gut microbiota may contribute to the therapeutic effect of naringenin against NASH.

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Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion

Leung,

Lo,

Chen

et al. 2023

Biomedicine & Pharmacotherapy

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Mechanistic insights into zearalenone-accelerated colorectal cancer in mice using integrative multi-omics approaches

Cited by 8 publications

References 46 publications

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

Exploring Impact of Probiotic‐Fermented Soymilk on Dextran‐Sulfate‐Sodium‐Induced Ulcerative Colitis via Modulating Inflammation and Gut Microbiota Profile

Naringenin prevents non‐alcoholic steatohepatitis by modulating the host metabolome and intestinal microbiome in MCD diet‐fed mice

Zearalenone attenuates colitis associated colorectal tumorigenesis through Ras/Raf/ERK pathway suppression and SCFA-producing bacteria promotion

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