Mechanistic Insight on the Interaction between OPN and Integrin ανβ3 in Osteoarthritis

Yuan, Yunchang; Liu, Qing; Wu, Ziyi; Luo, Wei

doi:10.1155/2020/2905634

Cited by 7 publications

(5 citation statements)

References 41 publications

(51 reference statements)

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“…OPN facilitates the attachment of osteoclasts to the bone matrix via interaction with cell surface αvβ3 integrin and CD44 ( 24 , 25 ). OPN interacts with receptors such as integrin and CD44 to regulate physiological and pathological processes of proliferation, differentiation, inflammation, metabolism and tumor metastasis in chondrocytes, osteoblasts and osteoclasts ( 26 – 28 ). Previous studies have shown that OPN is involved in the occurrence, repair and maintenance of cartilage and subchondral bone metabolic homeostasis, suggesting that OPN is an important regulator of OA and OP and plays an important role in chondrocyte and osteocyte metabolism by regulating the extracellular matrix components of articular cartilage subchondral bone components ( 10 , 29 , 30 ).…”

Section: The Structure and Function Of Opnmentioning

confidence: 99%

Osteopontin, a bridge links osteoarthritis and osteoporosis

Bai

Li²,

Zhang³

2022

Front. Endocrinol.

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Osteoarthritis (OA) is the most prevalent joint disease characterized by degradation of articular cartilage, inflammation, and changes in periarticular and subchondral bone of joints. Osteoporosis (OP) is another systemic skeletal disease characterized by low bone mass and bone mineral density (BMD) accompanied by microarchitectural deterioration in bone tissue and increased bone fragility and fracture risk. Both OA and OP are mainly affected on the elderly people. Recent studies have shown that osteopontin (OPN) plays a vital role in bone metabolism and homeostasis. OPN involves these biological activities through participating in the proliferation, migration, differentiation, and adhesion of several bone-related cells, including chondrocytes, synoviocytes, osteoclasts, osteoblasts, and marrow mesenchymal stem cells (MSCs). OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as OA and OP. This review summarizes the role of OPN in regulating inflammation activity and bone metabolism in OA and OP. Furthermore, some drugs that targeted OPN to treat OA and OP are also summarized in the review. However, the complex mechanism of OPN in regulating OA and OP is not fully elucidated, which drives us to explore the depth effect of OPN on these two bone diseases.

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Section: The Structure and Function Of Opnmentioning

confidence: 99%

Osteopontin, a bridge links osteoarthritis and osteoporosis

Bai

Li²,

Zhang³

2022

Front. Endocrinol.

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“…Under arthritic condition, inducible HAS2 expression plays pivotal roles. It is reported that the expression of HAS2 is increased in human OA chondrocytes 44,45 . Under of IL‐1α stimulation human articular cartilage will produce 3.5‐fold amounts of HAS2 46 .…”

Section: Discussionmentioning

confidence: 99%

“…It is reported that the expression of HAS2 is increased in human OA chondrocytes. 44,45 Under of IL-1α stimulation human articular cartilage will produce 3.5-fold amounts of HAS2. 46 Thus, HAS2 may not only act on the maintenance of ECM in articular cartilage, but may also be highly expressed in OA to maintain homeostasis.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head

Zhang

Nishida

Koike

et al. 2022

Journal Orthopaedic Research

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Hyaluronan (HA) plays crucial roles in the maintenance of high-quality cartilage extracellular matrix. Several studies have reported the HA in synovial fluid in patients with osteoarthritis (OA), but few have described the changes of HA in articular cartilage of OA or idiopathic osteonecrosis of the femoral head (ONFH). KIAA1199 was recently reported to have strong hyaluronidase activity. The aim of this study was to clarify the HA metabolism in OA and ONFH, particularly the involvement of KIAA1199. Immunohistochemical analysis of KIAA1199 and HA deposition was performed for human OA (n = 10), ONFH (n = 10), and control cartilage (n = 7). The concentration and molecular weight (MW) of HA were determined by competitive HA ELISA and Chromatography, respectively. Regarding HA metabolism-related molecules, HAS1, HAS2, HAS3, HYAL1, HYAL2, and KIAA1199 gene expression was assessed by reverse transcriptase polymerase chain reaction. Histological analysis showed the overexpression of KIAA1199 in OA cartilage, which was accompanied by decreased hyaluronic acid binding protein (HABP) staining compared with ONFH and control. Little KIAA1199 expression was observed in cartilage at the collapsed area of ONFH, which was accompanied by a slight decrease in HABP staining. The messenger RNA (mRNA) expression of HAS2 and KIAA1199 was upregulated in OA cartilage, while the mRNA expression of genes related to HA catabolism in ONFH cartilage showed mostly a downward trend. The MW of HA in OA cartilage increased while that in ONFH cartilage decreased. HA metabolism in ONFH is suggested to be generally indolent, and is activated in OA including high expression of KIAA1199. Interestingly, MW of HA in OA cartilage was not reduced.

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“…[101] The cross-talk between osteopontin (OPN), integrin 𝛼𝜈𝛽3, and HA was demonstrated in the osteoarthritis (OA) model, in which the expression of HA was regulated by the interaction between OPN and integrin 𝛼𝜈𝛽3. [106] The HA has been reported to interact with the ion channel of the nociceptor to exhibit an analgesic effect. The HA solution inhibited heat and capsaicin evokedintracellular calcium concentration in TRPV1-EYFP channels expressed in HEK293 cells and dorsal root ganglia culture and prevented TRPV1 sensitization by bradykinin, confirming the interaction of HA on TRPV1 channels of sensitized peripheral sensory terminals.…”

Section: Ha Derivatives As Cell-based Therapeuticsmentioning

confidence: 99%

Hyaluronic Acid‐Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential

Kotla

Isa

Larrañaga

et al. 2023

Adv Healthcare Materials

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In recent years, the development of hyaluronic acid or hyaluronan (HA) based scaffolds, medical devices, bioconjugate systems have expanded into a broad range of research and clinical applications. Research findings over the last two decades suggest that the abundance of HA in most mammalian tissues with distinctive biological roles and chemical simplicity for modifications have made it an attractive material with a rapidly growing global market. Besides its use as native forms, HA has received much interest on so‐called “HA‐bioconjugates” and “modified‐HA systems”. In this review, the importance of chemical modifications of HA, underlying rationale approaches, and various advancements of bioconjugate derivatives with their potential physicochemical, and pharmacological advantages are summarized. This review also highlights the current and emerging HA‐based conjugates of small molecules, macromolecules, crosslinked systems, and surface coating strategies with their biological implications, including their potentials and key challenges discussed in detail.

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Mechanistic Insight on the Interaction between OPN and Integrin ανβ3 in Osteoarthritis

Cited by 7 publications

References 41 publications

Osteopontin, a bridge links osteoarthritis and osteoporosis

Osteopontin, a bridge links osteoarthritis and osteoporosis

Hyaluronan in articular cartilage: Analysis of hip osteoarthritis and osteonecrosis of femoral head

Hyaluronic Acid‐Based Bioconjugate Systems, Scaffolds, and Their Therapeutic Potential

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