2018
DOI: 10.1002/jcp.27204
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Mechanistic insight into the attenuation of gouty inflammation by Taiwanese green propolis via inhibition of the NLRP3 inflammasome

Abstract: Dysregulation of NACHT, LRR, and PYD domains-containing protein 3 (NLRP3)inflammasome is involved in many chronic inflammatory diseases, including gouty arthritis. Activation of the NLRP3 inflammasome requires priming and activation signals: the priming signal controls the expression of NLRP3 and interleukin (IL)-1β precursor (proIL-1β), while the activation signal leads to the assembly of the NLRP3 inflammasome and to caspase-1 activation. Here, we reported the effects of the alcoholic extract of Taiwanese gr… Show more

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Cited by 42 publications
(46 citation statements)
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References 39 publications
(87 reference statements)
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“…Intracellular ROS production was measured by detecting the fluorescence intensity of 2 , 7 -dichlorofluorescein, the oxidation product of 2 , 7 -dichlorofluorescein diacetate (Molecular Probes, Eugene, OR, USA) as described previously [24,25]. In brief, 12-well plates (8 × 10 4 cells/well) with 0.1 mL of culture medium were grown overnight at 37 • C in a 5% CO 2 incubator.…”
Section: Detection Of Intracellular Ros Productionmentioning
confidence: 99%
“…Intracellular ROS production was measured by detecting the fluorescence intensity of 2 , 7 -dichlorofluorescein, the oxidation product of 2 , 7 -dichlorofluorescein diacetate (Molecular Probes, Eugene, OR, USA) as described previously [24,25]. In brief, 12-well plates (8 × 10 4 cells/well) with 0.1 mL of culture medium were grown overnight at 37 • C in a 5% CO 2 incubator.…”
Section: Detection Of Intracellular Ros Productionmentioning
confidence: 99%
“…However, little is known about the effects of 4-HAB on the NLRP3 inflammasome and the underlying molecular mechanism of these effects. As part of our efforts is to identify novel NLRP3 inflammasome inhibitors [11][12][13][14][15] and based on the known anti-inflammatory effects of 4-HAB, we hypothesized that 4-HAB can inhibit the NLRP3 inflammasome.…”
Section: Introductionmentioning
confidence: 99%
“…There is a clear need for safe and effective therapeutic regimens focusing on TIF to timely preserve renal function in patients with AAs intoxication, preventing from ESKD and fatal urothelial cancer in clinical medicine. PE, a potent natural antioxidant with multi-components, serves as a multi-targeted regimen in inflammation [ 12 ], diabetes [ 13 ], and cancers [ 15 ]. Our recent study unraveled that the scavenging of ROS by antioxidants ameliorates obesity-related kidney fibrosis [ 16 ].…”
Section: Discussionmentioning
confidence: 99%
“…All animals were randomly divided into four groups of six mice each: vehicle-treated control group (normal renal function), PE-treated group (normal renal function), AAN group and PE-treated AAN group. PE was collected in Taiwan using propolis collectors as described previously [ 12 ]. The dosage and experimental administration were presented here: Group I (control; IP injection of vehicle (DMSO, Sigma Aldrich, China) once every 3 days for 6 weeks and orally administered with vehicle (distilled water, 200 μL) everyday, 12 weeks; n = 6).…”
Section: Methodsmentioning
confidence: 99%
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