Mechanistic Insight into how β‐Ketoacyl ACP Synthase I (KasA) Recognizes the Fatty Acid Chain Length of its Substrate
Wook Lee
Abstract:Abstractβ‐ketoacyl ACP synthase I (KasA) has been considered as a promising drug target against Tuberculosis because it is known to play a pivotal role in the survival of Mycobacterium Tuberculosis, a causative agent of Tuberculosis. KasA catalyzes the reaction elongating only the acyl chain that is 16 carbon atoms in length or longer, but the molecular details of how KasA selectively recognizes only the substrate longer than a certain length still remain unknown. In the present study, this challenging subject… Show more
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