Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types

Sherman, Harry G.; Jovanovic, Carolyn; Abuawad, Alaa; Kim, Dong‐Hyun; Collins, Hilary M.; Dixon, James E.; Cavanagh, Robert; Márkus, Róbert; Stolnik, Snow; Rawson, Frankie J.

doi:10.1016/j.bbabio.2019.06.012

Cited by 15 publications

(15 citation statements)

References 74 publications

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“…asthma, [79] and there is now evidence that their activity is also altered in cancer cells [29,80,81] to alleviate cellular stress. [82] The shunt toward increased tPMET activity in cancer has been shown to rely on ascorbate metabolism, which is linked to NADPH and therefore the pentose phosphate shunt (PPP).…”

Section: Trans Plasma Membrane Electron Transport Systems (Tpmets)mentioning

confidence: 99%

“…tPMETs allow for the reduction of extracellular oxidants using electrons donated, from either intracellular or shuttled electron donors, to control cell growth and development. [ 78 ] Aberrant tPMETs have been linked to multiple other pathologies such as obesity, diabetes, and asthma, [ 79 ] and there is now evidence that their activity is also altered in cancer cells [ 29,80,81 ] to alleviate cellular stress. [ 82 ]…”

Section: The Relevance Of Bioelectrical Activity In Cancermentioning

confidence: 99%

“…This includes not only ionic currents, which have been extensively reviewed, [26,27] but also faradaic currents and the key links between them that we have postulated. [28,29]…”

mentioning

confidence: 99%

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Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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Bioelectronic medicine is a treatment modality that uses electricity to treat disease by altering the body's electrical communication systems. All cells are electrically active, in that they possess bioelectric circuitry generating a resting membrane potential and endogenous electric fields that influence cell functions and communication. There is now an accepted paradigm that cancer is characterized by malfunctions in cells' bioelectrical circuitry. This yields opportunities for bioelectronic medicine as novel treatments for cancer by manipulating its bioelectrical properties. To highlight the possibilities a bioelectrical approach can offer cancer therapy, the relevance of bioelectrical activity in cancer is reviewed and also how such activity can be hijacked in novel treatments. This includes sensing or measuring the electrical activity of cells for diagnostic and prognostic applications, controlling or altering bioelectricity including both ionic and faradaic current processes, and eliciting morphological changes using electric fields. Importantly, key links between cellular ionic and faradaic processes that contribute to cancer phenotypes are presented, which if considered and understood as a whole, can bring broad-reaching improvements to cancer therapy.

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Section: Trans Plasma Membrane Electron Transport Systems (Tpmets)mentioning

confidence: 99%

Section: The Relevance Of Bioelectrical Activity In Cancermentioning

confidence: 99%

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Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Robinson

Jain

Sherman

et al. 2021

Advanced Therapeutics

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“…[ 12 ] The need for VDACs to be “activated” and have their pores opened explains how they are non‐lethal, although the VDACS are thought to be involved in both ATP release and volume control [ 13 ] of the cytosol playing a regulatory role in apoptosis. VDACS and TPMETs are upregulated in various cancers; [ 14 ] and are involved in cancer development and progression. [ 15 ] VDACs have also been shown to play a role in apoptosis within differentiated neurons [ 16 ] and to be involved in amyloid beta toxicity in certain disease states including Alzheimers.…”

Section: Introductionmentioning

confidence: 99%

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins

Hicks

Yao

Barber

et al. 2021

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Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, the ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aims to develop a wireless bipolar electrochemical approach to form on‐demand electron transfer across biological membranes. To achieve this goal, it is shown that by using membrane inserted carbon nanotube porins (CNTPs) that can act as bipolar nanoelectrodes, one can control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. It is shown that bipolar electrochemical reaction via gold reduction at the nanotubes can be modulated at low cell‐friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. The authors provide new mechanistic insight into this newly describe phenomena at the nanoscale. The results presented give rise to a new method using CNTPs to modulate cell behavior via wireless control of membrane electron transfer.

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“…The need for VDACs to be 'activated' and have their pores opened explains how they are non-lethal, although the VDACS are thought to be involved in both ATP release and volume control 16 of the cytosol playing a regulatory role in apoptosis. VDACS and TPMETs are up-regulated in various cancers; 17 and are involved in cancer development and progression 18,19 . VDACs have also been shown to play a role in apoptosis within differentiated neurons 20 and to be involved in amyloid beta toxicity in certain disease states including Alzheimers 13 .…”

Section: Introductionmentioning

confidence: 99%

Electric Field Induced Biomimetic Transmembrane Electron Transport using Carbon Nanotube Porins as Bipolar Electrodes

Jm¹,

Ya²,

Barber³

et al. 2021

Preprint

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<p>Cells modulate their homeostasis through the control of redox reactions via transmembrane electron transport systems. These are largely mediated via oxidoreductase enzymes. Their use in biology has been linked to a host of systems including reprogramming for energy requirements in cancer. Consequently, our ability to modulate membrane redox systems may give rise to opportunities to modulate underlying biology. The current work aimed to develop a wireless bipolar electrochemical approach to form on-demand electron transfer across biological membranes. To achieve this goal, we show that using membrane inserted carbon nanotube porins that can act as bipolar nanoelectrodes, we could control electron flow with externally applied electric fields across membranes. Before this work, bipolar electrochemistry has been thought to require high applied voltages not compatible with biological systems. We show that bipolar electrochemical reaction via gold reduction at the nanotubes could be modulated at low cell-friendly voltages, providing an opportunity to use bipolar electrodes to control electron flux across membranes. Our observations present a new opportunity to use bipolar electrodes to alter cell behavior via wireless control of membrane electron transfer.</p>

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Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types

Cited by 15 publications

References 74 publications

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Toward Hijacking Bioelectricity in Cancer to Develop New Bioelectronic Medicine

Electric Field Induced Biomimetic Transmembrane Electron Transport Using Carbon Nanotube Porins

Electric Field Induced Biomimetic Transmembrane Electron Transport using Carbon Nanotube Porins as Bipolar Electrodes

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