Mechanistic Basis for the Role of Binary Mixtures Flowability and Related Factors in the Processability and Performance of High Shear and Extrusion Granulation
Abstract:The purpose of this study was to establish a relationship between the raw material properties and granulation behavior in extrusion wet granulation (WEG) and high shear wet granulation (HSWG). moisture content (MC), Carr index (CI), angle of repose (AOR), and mean size distribution (MSD) of binary mixtures were examined. The effect of these variables on the processibility and performance of the granulations was evaluated by monitoring such response along with granule growth. The prominent involved findings wer… Show more
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