Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review

Pathak, Rashmi; Sachan, Neetu; Chandra, Phool

doi:10.1016/j.biopha.2022.113025

Cited by 21 publications

(29 citation statements)

References 133 publications

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“…A Diabetes Mellitus é uma doença endócrina que afetou 5-15% da população mundial em 2020 (LEE et al, 2020), e cerca de 20%, em 2022 (PATHAK et al, 2022). Dos indivíduos que convivem com DM, 15% apresentam sinais e sintomas de polineuropatia e 50% apresentam anormalidades na condução nervosa (ROPPER & VICTOR, 2021).…”

Section: Epidemiologiaunclassified

“…É importante citar que o déficit sensitivo do paciente com ND frequentemente se inicia a partir de alterações na sensibilidade térmica e, por isso, o TQS mostra-se importante para o acompanhamento e rastreio de pacientes diabéticos. Entretanto, apesar do TQS permitir a detecção da ND ainda em estado subclínico, ele enfrenta alguns obstáculos -como variabilidade de reprodução e equipamentos de alto custo -, não sendo adequado como método diagnóstico isolado (PATHAK et al, 2022).…”

Section: Testes Diagnósticos Da Neuropatia Diabéticaunclassified

“…A Eletroneuromiografia (ENMG) pode contribuir na investigação da ND de forma objetiva e quantificável, porém é limitada ao passo que se mostra mais sensível a alterações em fibras nervosas grossas, enquanto que na ND as fibras nervosas finas são as primeiras a serem acometidas. Além disso, a ENMG possui alto custo associado e a necessidade de um examinador qualificado para a realização do exame (PATHAK et al, 2022).…”

Section: Testes Diagnósticos Da Neuropatia Diabéticaunclassified

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Neuropatia Periférica Diabética – Uma Revisão Da Literatura

SILVA¹,

SOUZA²,

SILVA³

et al. 2022

NEUROLOGIA: Diagnósticos, Tratamentos E Cirurgias - Edição II

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Section: Epidemiologiaunclassified

Section: Testes Diagnósticos Da Neuropatia Diabéticaunclassified

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Neuropatia Periférica Diabética – Uma Revisão Da Literatura

SILVA¹,

SOUZA²,

SILVA³

et al. 2022

NEUROLOGIA: Diagnósticos, Tratamentos E Cirurgias - Edição II

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“…Peripheral nerve degeneration has increased over the past few years affecting 2.8% of trauma subjects annually (14). PDN is likely to be associated with demyelination and axonal atrophy that leads to nerve degeneration as suggested by animal experiments (15,16). The patho-mechanistic approach leads to damage of peripheral nerve plexus in PDN including two major components.…”

Section: Introductionmentioning

confidence: 98%

New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review

et al. 2022

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BackgroundPeripheral nerve injury is a serious concern that leads to loss of neuronal communication that impairs the quality of life and, in adverse conditions, causes permanent disability. The limited availability of autografts with associated demerits shifts the paradigm of researchers to use biomaterials as an alternative treatment approach to recover nerve damage.PurposeThe purpose of this study is to explore the role of biomaterials in translational treatment approaches in diabetic neuropathy.Study designThe present study is a prospective review study.MethodsPublished literature on the role of biomaterials in therapeutics was searched for.ResultsBiomaterials can be implemented with desired characteristics to overcome the problem of nerve regeneration. Biomaterials can be further exploited in the treatment of nerve damage especially associated with PDN. These can be modified, customized, and engineered as scaffolds with the potential of mimicking the extracellular matrix of nerve tissue along with axonal regeneration. Due to their beneficial biological deeds, they can expedite tissue repair and serve as carriers of cellular and pharmacological treatments. Therefore, the emerging research area of biomaterials-mediated treatment of nerve damage provides opportunities to explore them as translational biomedical treatment approaches.ConclusionsPre-clinical and clinical trials in this direction are needed to establish the effective role of several biomaterials in the treatment of other human diseases.

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“…Diabetic patients are also prone to develop other morbidities such as liver and kidney dysfunction and lung injury (9). Ding et al describe a traditional Chinese medicine Jiangtang Tongmai Prescription (JTTMP) that activates SnoN and TGF-b1/ Smads signaling pathways to promote diabetic lung injury repair.…”

mentioning

confidence: 99%

Research advances in gestational, neonatal diabetes mellitus and metabolic disorders

2022

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Editorial on the Research TopicResearch advances in gestational, neonatal diabetes mellitus and metabolic disorders Diabetes mellitus (DM) is among the most common disorders affecting people of all ages across the globe from neonates to seniors (1). Indeed, DM has emerged as one of the major health concerns of this century with a huge economic burden that continues to grow, especially in low and middle-income counties (2). In addition to type 1 and II diabetes (T2DM), gestational diabetes mellitus (GDM) (3) and neonatal diabetes mellitus (NDM) are now more frequently reported (4). GDM poses significant dangers not only for the mother but also for the developing fetus (5). Unlike the common forms of diabetes, the causes and associated complications of GDM and NDM are not yet completely understood. However, diabetes may also be associated with metabolic syndromes (MetS), a medical term used for a combination of diabetes, high blood pressure (hypertension), and obesity (6). Diabetes also creates a greater risk for coronary heart disease, stroke, and other conditions affecting blood vessels, and notably in pregnancy, a relationship has been established between maternal MetS, GDM, and pregnancy outcomes (7). The current Research Topic aimed to collect studies reporting advancements in clinical and basic research related to GDM, NDM, and associated metabolic disorders. After a rigorous process of selection and review, the current volume presents an authoritative collection of 20 research articles exploring new dimensions in this topic.Firstly, introducing major players in metabolic disorders, Zhen et al. reviewed the role of kynurenic acid (KYNA) in the pathogenesis and development of several human endocrine and metabolic diseases. KYNA is a signaling molecule and a major player in metabolic diseases inclusive of diabetes and obesity. Their study promotes the notion that Frontiers in Endocrinology frontiersin.org 01

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Mechanistic approach towards diabetic neuropathy screening techniques and future challenges: A review

Cited by 21 publications

References 133 publications

Neuropatia Periférica Diabética – Uma Revisão Da Literatura

Neuropatia Periférica Diabética – Uma Revisão Da Literatura

New horizons of biomaterials in treatment of nerve damage in diabetes mellitus: A translational prospective review

Research advances in gestational, neonatal diabetes mellitus and metabolic disorders

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