Mechanistic and kinetic aspects of Natamycin interaction with serum albumin using spectroscopic and molecular docking methods

Azimirad, Maryam; Javaheri-Ghezeldizaj, Fatemeh; Yekta, Reza; Dolatabadi, Jafar Ezzati Nazhad; Torbati, Mohammadali

doi:10.1016/j.arabjc.2023.105043

Arabian Journal of Chemistry

2023

DOI: 10.1016/j.arabjc.2023.105043

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Mechanistic and kinetic aspects of Natamycin interaction with serum albumin using spectroscopic and molecular docking methods

Maryam Azimirad

Fatemeh Javaheri-Ghezeldizaj

Reza Yekta

et al.

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Cited by 8 publications

References 57 publications

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Novel pH‐sensitive gellan gum–ε‐polylysine hydrogel microspheres for sulforaphene delivery

Qu,

Li,

Chen

et al. 2024

J Sci Food Agric

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BACKGROUNDThis study aimed to improve the stability and utilization of sulforaphene (SFE) and to enhance the intestinal stability and pH‐sensitive release of SFE in the gastrointestinal tract. To achieve this objective, calcium chloride (CaCl2) was used as a crosslinking agent to fabricate novel SFE‐loaded gellan gum (GG)‐ε‐polylysine (ε‐PL) pH‐sensitive hydrogel microspheres by using the ionic crosslinking technique.RESULTSThe molecular docking results of GG, ε‐PL, and SFE were good and occurred in the natural state. The loading efficiency (LE) of all samples was above 70%. According to the structural characterization results, GG and ε‐PL successfully embedded SFE in a three‐dimensional network structure through electrostatic interaction. The swelling characteristics and in vitro release results revealed that the microspheres were pH‐sensitive, and SFE was mainly retained inside the hydrogel microsphere in the stomach, and subsequently released in the intestine. The result of cytotoxicity assay showed that the hydrogel microspheres were non‐toxic and had an inhibitory effect on human colon cancer Caco‐2 cells.CONCLUSIONThus, the hydrogel microspheres could improve SFE stability and utilization and achieve the intestinal targeted delivery of SFE. © 2024 Society of Chemical Industry.

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Novel pH‐sensitive gellan gum–ε‐polylysine hydrogel microspheres for sulforaphene delivery

Qu,

Li,

Chen

et al. 2024

J Sci Food Agric

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Gamma globulin binding of hinokiflavone with anti-osteoporosis effects: A mechanistic study

Zhang,

et al. 2024

Arabian Journal of Chemistry

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Unraveling the binding behavior of the antifouling biocide 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one with human serum albumin: Multi-spectroscopic, atomic force microscope, computational simulation, and esterase activity

Zhou,

Li,

Cheng

et al. 2024

International Journal of Biological Macromolecules

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Mechanistic and kinetic aspects of Natamycin interaction with serum albumin using spectroscopic and molecular docking methods

Cited by 8 publications

References 57 publications

Novel pH‐sensitive gellan gum–ε‐polylysine hydrogel microspheres for sulforaphene delivery

Novel pH‐sensitive gellan gum–ε‐polylysine hydrogel microspheres for sulforaphene delivery

Gamma globulin binding of hinokiflavone with anti-osteoporosis effects: A mechanistic study

Unraveling the binding behavior of the antifouling biocide 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one with human serum albumin: Multi-spectroscopic, atomic force microscope, computational simulation, and esterase activity

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