Mechanistic analysis of experimental food allergen-induced cutaneous reactions

Prescott, Vanessa; Forbes, Elizabeth; Foster, Paul S.; Matthaei, Klaus I.; Hogan, Simon P.

doi:10.1189/jlb.1105637

Cited by 23 publications

(13 citation statements)

References 63 publications

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“…Moreover, the binding of IgE and OVA on mast cells and eosinophils was detected outside blood vessels. However, there was no infiltration of CLA + lymphocytes, which were characteristically seen in late hypersensitivity reaction and CD4 + T lymphocytes are thought to regulate eosinophil recruitment to the site of allergic skin reaction through the activity of Th2 cytokines (Prescott et al. 2006).…”

Section: Discussioncontrasting

confidence: 99%

“…However, the mechanisms which lead to the development of systemic element, and particularly the mechanisms of distant manifestations after a local allergic reaction have not been elucidated (Togias 2004). Possibilities of the development of cutaneous lesions in humans with food and milk allergy include locally and systemically produced cytokines, chemokines and several chemical mediators (Prescott et al. 2006).…”

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confidence: 99%

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Acute uriticaria‐like lesions in allergen‐unexposed cutaneous tissues in a mouse model of late allergic rhinitis

Hayashi

Fujii

2008

Int J Experimental Path

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Summary The mechanisms of distant manifestation after a local allergic reaction are largely unknown. This study examined the development of cutaneous lesions in a mouse model of late allergic rhinitis (LAR). BALB/c mice were sensitized by ovalbumin (OVA) intraperitoneally two times (on days 0 and 10) and challenged by OVA intranasally on day 14. Four days after OVA challenge, nasal and cutaneous lesions including helper T (Th) responses, expression of adhesion molecules and presence of OVA and IgE were examined, and compared with unsensitized and unchallenged (control) mice. Compared with the control group, the LAR group developed LAR characterized by infiltration of lymphocytes and eosinophils, increased IgE values and increased productions of IL‐4 and IL‐5, but not IFN‐γ. A dominant infiltration of eosinophils and increase in mast cells, attachment of eosinophils to endothelium, intense expression of VCAM‐1 on endothelium in venules and VLA‐4 expression on eosinophils and mast cells were recognized in the cutaneous tissues. There were no differences in the expression of ICAM‐1 on vascular endothelium and LFA‐1 on infiltrated leucocytes between the two groups. CLA expression on lymphocytes was not detected, and the binding of OVA and IgE on mast cells and eosinophils was found in the cutaneous lesions in the LAR group, but not in the control group. This study suggests that acute uriticaria‐like lesions in OVA‐unexposed cutaneous tissues may be induced by immediate allergic reaction due to the systemic development of Th2‐type response in a mouse model of LAR.

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Section: Discussioncontrasting

confidence: 99%

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confidence: 99%

Acute uriticaria‐like lesions in allergen‐unexposed cutaneous tissues in a mouse model of late allergic rhinitis

Hayashi

Fujii

2008

Int J Experimental Path

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“…Our results are at odds with the previous study in which mice developed allergic responses to αAI peas but not to beans [8], [16]. It is possible that the source of the mice and their normal baseline diets may play a role.…”

Section: Resultscontrasting

confidence: 99%

Genetically Modified α-Amylase Inhibitor Peas Are Not Specifically Allergenic in Mice

et al. 2013

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Weevils can devastate food legumes in developing countries, but genetically modified peas (Pisum sativum), chickpeas and cowpeas expressing the gene for alpha-amylase inhibitor-1 (αAI) from the common bean (Phaseolus vulgaris) are completely protected from weevil destruction. αAI is seed-specific, accumulated at high levels and undergoes post-translational modification as it traverses the seed endomembrane system. This modification was thought to be responsible for the reported allergenicity in mice of the transgenic pea but not the bean. Here, we observed that transgenic αAI peas, chickpeas and cowpeas as well as non-transgenic beans were all allergenic in BALB/c mice. Even consuming non-transgenic peas lacking αAI led to an anti-αAI response due to a cross-reactive response to pea lectin. Our data demonstrate that αAI transgenic peas are not more allergenic than beans or non-transgenic peas in mice. This study illustrates the importance of repeat experiments in independent laboratories and the potential for unexpected cross-reactive allergic responses upon consumption of plant products in mice.

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“…42 Several studies have found increased levels of the Th2-associated cytokines IL-4, IL-5 and IL-13 in food allergic patients and mouse models of food allergy. 85–89 Additionally, mutations in IL-4 Receptor A ( IL-4RA ) and IL-13 are associated with increased risk of food allergy, highlighting the importance of Th2 cytokine signaling in food allergy. 90, 91 Blockade of IL-4 and IL-13 signaling with the anti-IL-4Rα antibody dupilumab, successfully improved the clinical symptoms of subjects with asthma or atopic dermatitis, though other therapies blocking IL-4, IL-13 or IL-5 individually have been less effective.…”

Section: Modulating Th1/th2 Imbalancementioning

confidence: 99%

The future of biologics: Applications for food allergy

Bauer

Manohar

Singh

et al. 2015

Journal of Allergy and Clinical Immunology

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Allergic diseases affects millions worldwide, with growing evidence of an increase in allergy occurrence over the past few decades. Current treatments for allergy include corticosteroids to reduce inflammation and allergen immunotherapy (AIT); however, some individuals experience treatment-resistant inflammation or adverse reactions to these treatments, and neither are currently approved for the treatment of food allergy. There is a dire need for new therapeutic approaches for individuals with poorly controlled atopic diseases and to improve the safety and effectiveness of AIT. Improved understanding of allergy through animal models and clinical trials has unveiled potential targets for new therapies, leading to the development of several biologics to treat allergic diseases. This review focuses on the mechanisms that contribute to allergy, with an emphasis on future targets for biologics for the treatment of food allergy. These biologics include immunotherapy with novel anti-IgE antibodies and analogs, small molecule inhibitors of cell signaling, anti-type 2 cytokine monoclonal antibodies and Th1-promoting adjuvants.

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Mechanistic analysis of experimental food allergen-induced cutaneous reactions

Cited by 23 publications

References 63 publications

Acute uriticaria‐like lesions in allergen‐unexposed cutaneous tissues in a mouse model of late allergic rhinitis

Acute uriticaria‐like lesions in allergen‐unexposed cutaneous tissues in a mouse model of late allergic rhinitis

Genetically Modified α-Amylase Inhibitor Peas Are Not Specifically Allergenic in Mice

The future of biologics: Applications for food allergy

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