Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression

Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway

“…The expressions of PGC-1α protein and mRNA were both lower than CG. This agrees to the results of studies by Fang et al [46], Odaira et al [47], and Agudelo et al [48], which indicates that the AMPK /PGC-1 signaling pathway factor is activated by chronic stress and that AMPK energy metabolism pathway disorders happen in the skeletal muscles of depression patients. In contrast to the results of this experimental study, Cao et al [49] found that mice with chronic social failure had lower levels of ATP in the brain.…”

Proteomic profiling of the neurons in mice with depressive-like behavior induced by corticosterone and the regulation of berberine: pivotal sites of oxidative phosphorylation

“…Recent studies suggest that the beneficial effect of antidepressant drugs is mediated via stimulation of adult hippocampal neurogenesis and subsequent increase in hippocampal plasticity. Changes in hippocampal neurons can play an important role in the pathogenesis of depression, involving the possible mechanism of ERK (extracellular signal-regulated kinase) pathway [7], AMPK (Adenosine monophosphate-activated protein kinase) pathway [8], GABAergic dysfunction in the nucleus accumbens (NAc) [9], epigenetic events altering the chromatin structure and thus modulating expression of genes [10], Sirt1 (silent information regulator 1) at the consumption of NAD+ [11], BDNF pathway [12,13], etc. However, mitochondrial energy metabolism in depression remains poorly understood although the action of the above mentioned signalings, at least in part, relies on energy metabolism.…”

Scabronine G Methyl Ester Improves Memory-Related Behavior and Enhances Hippocampal Cell Proliferation and Long-Term Potentiation via the BDNF-CREB Pathway in Olfactory Bulbectomized Mice

“…In previous study, Obara et al demonstrated that SG-ME enhanced neurotrophic factors biosynthesis, which plays critical roles in memory and cognitive functions, via PKC-ζ and possibly nuclear factor-kappa B (NF-κB) (Obara et al, 2001). Moreover, we reported that the cell proliferation promoted via the PKCζ/NF-κB/BDNF/TrkB/CREB signaling pathway in hippocampal precursor neurons occurred concomitantly with an antidepressant effect in OBX mice (Odaira et al, 2019). The present PAT showed that the PKC-ζ inhibitor zeta inhibitory peptide (ZIP) attenuated the SG-ME-induced improvement in memory deficits in OBX mice [ Figure 2A].…”

“…Surgical OBX was performed as previously described (Hozumi et al, 2003;Odaira et al, 2019). The mice were anesthetized with sodium pentobarbital (50 mg/kg; Kyoritsu Seiyaku, Tokyo, Japan) and subsequently placed on a stereotaxic instrument.…”