Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad

Ge, Yongtong; Cheng, Dalei; Jia, Qingzhi; Xiong, Huabao; Zhang, Junfeng

doi:10.4110/in.2021.21.e21

Cited by 16 publications

(8 citation statements)

References 144 publications

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“…Memory B cells and MDSC, including immature granulocytes, macrophages, and DCs at different stages of differentiation, are well-known immunosuppressive cells that play a decisive role in many disease states [ 57 ]. Recent studies have reported that MDSC can be recruited to the infarcted myocardium during the acute phase of acute myocardial infraction to induce the secretion of protein hydrolases and promote apoptosis [ 58 – 60 ]. In a mouse IS model, IS was found to increase the number of PMN-MDSC-LCs in the bone marrow, spleen, and ischemic hemisphere, further suggesting an important role of MDSC in cardiac and cerebral ischemia [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia

Liao

Yang

et al. 2023

BMC Genomics

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Background There is a mutual hemodynamic and pathophysiological basis between the heart and brain. Glutamate (GLU) signaling plays an important role in the process of myocardial ischemia (MI) and ischemic stroke (IS). To further explore the common protective mechanism after cardiac and cerebral ischemic injuries, the relationship between GLU receptor-related genes and MI and IS were analyzed. Results A total of 25 crosstalk genes were identified, which were mainly enriched in the Toll-like receptor signaling pathway, Th17 cell differentiation, and other signaling pathways. Protein-protein interaction analysis suggested that the top six genes with the most interactions with shared genes were IL6, TLR4, IL1B, SRC, TLR2, and CCL2. Immune infiltration analysis suggested that immune cells such as myeloid-derived suppressor cells and monocytes were highly expressed in the MI and IS data. Memory B cells and Th17 cells were expressed at low levels in the MI and IS data; molecular interaction network construction suggested that genes such as JUN, FOS, and PPARA were shared genes and transcription factors; FCGR2A was a shared gene of MI and IS as well as an immune gene. Least absolute shrinkage and selection operator logistic regression analysis identified nine hub genes: IL1B, FOS, JUN, FCGR2A, IL6, AKT1, DRD4, GLUD2, and SRC. Receiver operating characteristic analysis revealed that the area under the curve of these hub genes was > 65% in MI and IS for all seven genes except IL6 and DRD4. Furthermore, clinical blood samples and cellular models showed that the expression of relevant hub genes was consistent with the bioinformatics analysis. Conclusions In this study, we found that the GLU receptor-related genes IL1B, FOS, JUN, FCGR2A, and SRC were expressed in MI and IS with the same trend, which can be used to predict the occurrence of cardiac and cerebral ischemic diseases and provide reliable biomarkers to further explore the co-protective mechanism after cardiac and cerebral ischemic injury.

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Section: Discussionmentioning

confidence: 99%

Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia

Liao

Yang

et al. 2023

BMC Genomics

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“… 26 , 73 , 74 Increased expression of IL-1β under inflammatory environments induces the attraction of MDSCs and increases the levels of IL-10 and Arg-1 in MDSCs. 56 , 75 – 78 The levels of the inflammatory cytokines, TNF-α and IL-1β, are increased in the retinal and choroidal tissues in EAU. Previous studies have reported that the majority of infiltrated cells within the retina after uveitis inflammation were F4/80 + macrophages, which could produce proinflammatory cytokines, such as IL-1β and TNF-α, and contribute to uveitis-associated inflammation.…”

Section: Discussionmentioning

confidence: 99%

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Lee,

Kim,

Sohn

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Purpose To evaluate the immune regulatory effect of human cord blood myeloid-derived suppressor cells (MDSCs) in experimental autoimmune uveitis (EAU) models. Methods MDSCs (1 × 10 6 ) or PBS were injected into established C57BL/6 EAU mice via the subconjunctival route on days 0 and 7. The severity of intraocular inflammation was evaluated for up to 3 weeks. Tissue injury and inflammation were analyzed using immunolabelled staining, real-time PCR, and ELISA. In addition, immune cells in draining lymph nodes (LNs) were quantified using flow cytometry. Results After 21 days, the clinical scores and histopathological grades of EAU were lower in the MDSCs group compared with the PBS group. Local administration of MDSCs suppressed the oxidative stress and the expression of TNF-α and IL-1β in the retinal tissues. In addition, it inhibited the activation of pathogenic T helper 1 (Th1) and Th17 cells in draining LNs. MDSCs increased the frequency of CD25 + Foxp3 + regulatory T cells and the mRNA expression of IL-10, as an immune modulator. Conclusions MDSCs suppressed inflammation and oxidative stress in the retina and inhibited pathogenic T cells in the LNs in EAU. Therefore, ocular administration of MDSCs has therapeutic potential for uveitis.

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“…In a healthy state, immature myeloid cells may be produced in the bone marrow and develop into mature granulocytes, macrophages, or dendritic cells, which then penetrate the proper tissues and organs to execute typical immune tasks. However, their normal differentiation is hindered in pathological settings such as tumors, infectious diseases, and autoimmune diseases, and MDSCs can rapidly accumulate and be activated through injury-associated molecular patterns or pathogen-associated molecular patterns, etc., by promoting reactive oxygen species (ROS) release; expressing high levels of arginase-1 (Arg-1) ( 22 ) and inducible nitric oxide synthase (iNOS) ( 23 ), promoting the release of interleukin (IL)-10, IL-1β, IL-6, tumor necrosis factor (TNF)-α and other cytokine ( 10 , 24 – 27 ), and the immunosuppressive activity of M-MDSCs was stronger than that of PMN-MDSCs ( 16 , 28 – 30 ). The mechanism of MDSCs in infectious lung diseases is shown in Figure 1 .…”

Section: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

Advances in the study of myeloid-derived suppressor cells in infectious lung diseases

Zhang

Yuan

2023

Front. Immunol.

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Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature cells capable of inhibiting T-cell responses. MDSCs have a crucial role in the regulation of the immune response of the body to pathogens, especially in inflammatory response and pathogenesis during anti-infection. Pathogens such as bacteria and viruses use MDSCs as their infectious targets, and even some pathogens may exploit the inhibitory activity of MDSCs to enhance pathogen persistence and chronic infection of the host. Recent researches have revealed the pathogenic significance of MDSCs in pathogens such as bacteria and viruses, despite the fact that the majority of studies on MDSCs have focused on tumor immune evasion. With the increased prevalence of viral respiratory infections, the resurgence of classical tuberculosis, and the advent of medication resistance in common bacterial pneumonia, research on MDSCs in these illnesses is intensifying. The purpose of this work is to provide new avenues for treatment approaches to pulmonary infectious disorders by outlining the mechanism of action of MDSCs as a biomarker and therapeutic target in pulmonary infectious diseases.

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Mechanisms Underlying the Role of Myeloid-Derived Suppressor Cells in Clinical Diseases: Good or Bad

Cited by 16 publications

References 144 publications

Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia

Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia

Local Myeloid-Derived Suppressor Cells Impair Progression of Experimental Autoimmune Uveitis by Alleviating Oxidative Stress and Inflammation

Advances in the study of myeloid-derived suppressor cells in infectious lung diseases

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