Mechanisms underlying the protective effects of blueberry extract against ultraviolet radiation in a skin cell co-culture system

Wang, Huailing; Liu, Jie; Pang, Daorui; Li, Tong; Liu, Rui Hai

doi:10.1016/j.jff.2018.11.037

Cited by 19 publications

(8 citation statements)

References 40 publications

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“… [ 82 ] “Bluecrop” blueberry extract (BE)

Cell line HaCaT, HFF Treatment with BE reduced the levels of transcription of inflammatory cytokine genes including TNF-α, IL-1β, IL-8, and IL-6. [ 83 ] Delphinidin

SKH-1 Mice Topical application of delphinidin in SKH-1 hairless mice inhibited apoptosis mediated by UV and DNA damage markers, such as cyclobutane pyrimidine dimers. [ 78 ] Cyanidin-3-glucoside

SKH-1 Mice Inhibited DNA damage and skin inflammation in SKH-1 hairless mice.…”

Section: Chemopreventionmentioning

confidence: 99%

Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity

Maya-Cano

Arango-Varela

Santa-González

2021

Heliyon

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The skin is a tissue with a high metabolic activity that acts as a protective layer for the internal organs of the body. This tissue is exposed to a variety of damaging agents, including reactive oxygen species (ROS), which can lead to oxidative damage to various macromolecules, disrupting vital cellular processes and increasing mutations. A situation referred to as oxidative stress occurs when a large amount of oxidants exceeds the capacity of the antioxidant defense system. Oxidative stress is considered a contributory factor to the aging process and the pathogenesis of various skin diseases, including cancer. Several current studies seek to identify new natural compounds with properties that mitigate the harmful effects of ROS, thereby acting as blockers or suppressors of the carcinogenesis process. This review briefly presents the relationship between ultraviolet radiation, ROS, and skin damage; and summarizes the in vitro and in vivo experimental evidence of the chemopreventive effect on skin cancer of phenolic compounds from blueberries ( Vaccinium spp ). Although several studies addressed the topic of bioactive compounds and their activities as possible anticancer agents, none have focused on the antioxidative action and antiproliferative effects on skin cancer of phenolic compounds derived from blueberries.

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“… [ 82 ] “Bluecrop” blueberry extract (BE)

Cell line HaCaT, HFF Treatment with BE reduced the levels of transcription of inflammatory cytokine genes including TNF-α, IL-1β, IL-8, and IL-6. [ 83 ] Delphinidin

SKH-1 Mice Topical application of delphinidin in SKH-1 hairless mice inhibited apoptosis mediated by UV and DNA damage markers, such as cyclobutane pyrimidine dimers. [ 78 ] Cyanidin-3-glucoside

SKH-1 Mice Inhibited DNA damage and skin inflammation in SKH-1 hairless mice.…”

Section: Chemopreventionmentioning

confidence: 99%

Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity

Maya-Cano

Arango-Varela

Santa-González

2021

Heliyon

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“…5d). The positive synergistic effect of excellent antioxidant activity and UV-shielding performance provides such composite lms great application potential for the repair of skin damage caused by UV illumination (Li et al 2019;Wang et al 2019). Moreover, the UGS-PVA lm possessed antimicrobial properties (Fig.…”

Section: Multiple Functions Of Ugs-pva Lmsmentioning

confidence: 99%

Multifunctional composite film based on biodegradable grape skin and polyvinyl alcohol

et al. 2021

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In winemaking, large amounts of grape skin (GS) are produced as by-products, which contain not only abundant degradable cellulose, hemicellulose, and pectin but various functional polyphenols. In contrast to most studies focusing on the utilization of extractives, the current study investigates the use of an ultrasonicated grape skin (UGS) containing all components to develop a multifunctional composite lm.Owing to dissociation during ultrasonication, all GS components were well dispersed in water to obtain the UGS suspension. Transmission electron microscopy (TEM) indicated that the celluloses were successfully transformed into cellulose nano bers (CNFs), which can improve the uniformity of the composite lm. Subsequently, biodegradable and multifunctional composite lms were fabricated by combining the UGS and polyvinyl alcohol (PVA). The UGS and PVA formed a good interface owing to strong hydrogen bonds, and the resulting lms exhibited excellent thermal stability and moisture-sensitive mechanical properties. The polyphenols in the UGS suspension endowed the composite lm with multiple functions, including pH-responsive color change, excellent antioxidant activity, ultraviolet shielding, and antimicrobial properties. The use of PVA enhanced the exibility, strength, and elongation of the UGS lm.The easily prepared, tailored, multifunctional, and biodegradable UGS/PVA composite lm exhibits excellent potential for application in agriculture, cosmetics, and healthcare.

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“…One of these models allowed the demonstration that coumestrol has a preventive effect on photoaging of the skin [147]. Other BASS models have underlined the protective effect of bilberry extract against UV light, discouraging DNA fragmentation and inhibiting the expression of inflammatory factors [148]. Additionally, a natural killer cell conditioned medium (NK-CdM) has been found to possess potent antioxidant activity on the skin by inhibiting collagen degradation.…”

Section: Impact Of Ultraviolet Radiationmentioning

confidence: 99%

Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

et al. 2020

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This review aims to be an update of Bioengineered Artificial Skin Substitutes (BASS) applications. At the first moment, they were created as an attempt to replace native skin grafts transplantation. Nowadays, these in vitro models have been increasing and widening their application areas, becoming important tools for research. This study is focus on the ability to design in vitro BASS which have been demonstrated to be appropriate to develop new products in the cosmetic and pharmacology industry. Allowing to go deeper into the skin disease research, and to analyze the effects provoked by environmental stressful agents. The importance of BASS to replace animal experimentation is also highlighted. Furthermore, the BASS validation parameters approved by the OECD (Organisation for Economic Co-operation and Development) are also analyzed. This report presents an overview of the skin models applicable to skin research along with their design methods. Finally, the potential and limitations of the currently available BASS to supply the demands for disease modeling and pharmaceutical screening are discussed.

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Mechanisms underlying the protective effects of blueberry extract against ultraviolet radiation in a skin cell co-culture system

Cited by 19 publications

References 40 publications

Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity

Phenolic compounds of blueberries (Vaccinium spp) as a protective strategy against skin cell damage induced by ROS: A review of antioxidant potential and antiproliferative capacity

Multifunctional composite film based on biodegradable grape skin and polyvinyl alcohol

Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis

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