Mechanisms underlying the laxative effect of lactulose: A randomized placebo‐controlled trial showing increased small bowel water and motility unaltered by the 5‐HT3 receptor antagonist, ondansetron
D. Gunn,
C. Yeldho,
C. Hoad
et al.
Abstract:BackgroundLactulose is a laxative which accelerates transit and softens stool. Our aim was to investigate its mechanism of action and use this model of diarrhea to investigate the anti‐diarrheal actions of ondansetron.MethodsA double‐blind, randomized, placebo‐controlled crossover study of the effect of ondansetron 8 mg in 16 healthy volunteers. Serial MRI scans were performed fasted and 6 h after a meal. Participants then received lactulose 13.6 g twice daily and study drug for a further 36 h. On Day 3, they … Show more
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