Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats

Raschka, Ladislav; Daniel, Hannelore

doi:10.1016/j.bone.2005.05.015

Cited by 115 publications

(98 citation statements)

References 29 publications

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“…Another way to contribute to the enhanced mineral absorption is the trophic effect of prebiotics on the gut (cell growth and functional enhancement of the absorptive area). It has been suggested that this is mediated by an increased production of butyrate and/or certain polyamines (Roberfroid 1993;Raschka and Daniel 2005).…”

Section: Improving Mineral Adsorptionmentioning

confidence: 99%

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

Dominguez

Rodrigues

Lima

et al. 2013

Food Bioprocess Technol

137

108

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Over the past years, many researchers have suggested that deficiencies in the diet can lead to disease states and that some diseases can be avoided through an adequate intake of relevant dietary components. Recently, a great interest in dietary modulation of the human gut has been registered. Prebiotics, such as fructooligosaccharides (FOS), play a key role in the improvement of gut microbiota balance and in individual health. FOS are generally used as components of functional foods, are generally regarded as safe (generally recognized as safe status-from the Food and Drug Administration, USA), and worth about 150€ per kilogram. Due to their nutrition-and health-relevant properties, such as moderate sweetness, low carcinogenicity, low calorimetric value, and low glycemic index, FOS have been increasingly used by the food industry. Conventionally, FOS are produced through a two-stage process that requires an enzyme production and purification step in order to proceed with the chemical reaction itself. Several studies have been conducted on the production of FOS, aiming its optimization toward the development of more efficient production processes and their potential as food ingredients. The improvement of FOS yield and productivity can be achieved by the use of different fermentative methods and different microbial sources of FOSproducing enzymes and the optimization of nutritional and culture parameter; therefore, this review focuses on the latest progresses in FOS research such as its production, functional properties, and market data.

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Section: Improving Mineral Adsorptionmentioning

confidence: 99%

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

Dominguez

Rodrigues

Lima

et al. 2013

Food Bioprocess Technol

137

108

View full text Add to dashboard Cite

show abstract

“…Although the small intestine is the principal site of calcium absorption in humans, significant amounts may be absorbed throughout the length of the gut, consequently maximising of colonic effects is desirable. Numerous animal studies have indicated that prebiotics increase calcium, zinc and magnesium absorption from the colon (Delzenne et al, 1995;Younes et al, 2001;Coudray et al, 2003;Raschka & Daniel, 2005a), resulting in increased bone density and bone trabecular structure (Ohta et al, 2002;Scholz-Ahrens et al, 2002;Raschka & Daniel, 2005b). Raschke and Daniel (2005b) reported increased absorption, retention and femur content of calcium, zinc and magnesium in a rat model only when the basic diet of the control group contained no intrinsic fructans and when the mineral demand was particularly high, as during growth.…”

Section: Increased Mineral Absorptionmentioning

confidence: 99%

“…Other mechanisms that have been proposed include an increased capacity of the calcium transporters (calbindin) in the colon (Ohta et al, 1998), suppression of bone resorption rate relative to bone formation rate (Zafar et al, 2004), release of bone-modulating factors such as phytoestrogens (Ohta et al, 2002) and improvement in gut health and gut-associated immune defence (Scholz-Ahrens et al, 2007). Raschka and Daniel (2005a) studied the effects of fermentation of inulin-type fructans on transepithelial calcium transport in the large intestine of rats. They found that fructan feeding altered transcript levels of several mucosa genes that can be linked to transcellular and paracellular calcium transport processes.…”

Section: Modulation Of the Immune Systemmentioning

confidence: 99%

Prebiotics: An update

Venter¹

2010

jfecs

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Prebiotics: an update OpsommingEen van die opwindendste tendense in die hedendaagse voedselbedryf is die soeke na funksionele voedsels, oftewel voedsels wat gesondheid bevorder en/of die risiko vir chroniese siektes verlaag, bo en behalwe die voedingswaarde daarvan. In hierdie opsig speel probiotika en prebiotika 'n belangrike rol. Probiotika (voedsels wat lewendige mikrobes bevat) is alombekend en word geassosieer met 'n hele aantal gesondheidsvoordele. Prebiotika (selektief gefermenteerde voedselbestanddele wat die samestelling en/of aktiwiteit van gastro -intestinale mikroflora verander tot voordeel van die gasheer se gesondheid en welsyn) is 'n meer onlangse konsep, gedefinieer in 1995. Hierdie artikel gee 'n oorsig van die jongste navorsing oor die gesondheidsvoordele van prebiotika en daar word kortliks verwys na die tegnologiese voordele daarvan in voedselformulerings. Die meeste van die navorsing is gedoen met die fruktosepolimere inulien en frukto-oligosaggariede, wat in hierdie artikel as voorbeelde van prebiotika gebruik word. Inulien en frukto-oligosaggariede is funksionele voedselbestanddele wat 'n unieke kombinasie van voedingkundige eienskappe en tegnologiese voordele bied. Dit kom voor in verskeie groentes en vrugte en word industrieel uit sigoreiwortels en sukrose vervaardig. Selektiewe fermentering daarvan moduleer gastro-intestinale mikroflora in so 'n mate dat dit hardlywigheid kan verlig, mineraalabsorpsie kan verbeter, kanker kan voorkom en lipiedmetabolisme en die immuunstelsel voordelig kan beïnvloed. Verdere navorsing is egter nodig om sodanige aansprake te bevestig en meganismes van werking op te klaar. -Dr CS Venter

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“…Um gradiente de concentração de cálcio mínimo entre a mucosa e a serosa intestinal é necessário para a absorção eficiente de cálcio solúvel no ceco e no cólon proximal e distal (RASCHKA & DANIEL, 2005). A presença de grande quantidade de ácidos graxos de cadeia curta no ceco, principalmente acetato, butirato e propionato, proporciona a diminuição do pH intraluminal (CAMPBELL et al, 1997) e o aumento da solubilidade do cálcio (LOPEZ et al, 1998).…”

Section: Introductionunclassified

“…A presença de grande quantidade de ácidos graxos de cadeia curta no ceco, principalmente acetato, butirato e propionato, proporciona a diminuição do pH intraluminal (CAMPBELL et al, 1997) e o aumento da solubilidade do cálcio (LOPEZ et al, 1998). Como resultado, há um aumento no gradiente de concentração, promovendo a entrada passiva de cálcio através do transporte transepitelial (RASCHKA & DANIEL, 2005). Entretanto, apesar das evidências do aumento do transporte de cálcio no intestino grosso, pela ação dos ácidos de origem fermentativa, nesse local ocorre a menor parte da absorção do cálcio da dieta (BRONNER & PANSU, 1999), tornando pequena essa contribuição.…”

Section: Introductionunclassified

Inclusão de ácidos graxos de cadeia curta em diferentes níveis de cálcio na dieta de frangos de corte

2009

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Mechanisms underlying the effects of inulin-type fructans on calcium absorption in the large intestine of rats

Cited by 115 publications

References 29 publications

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

An Overview of the Recent Developments on Fructooligosaccharide Production and Applications

Prebiotics: An update

Inclusão de ácidos graxos de cadeia curta em diferentes níveis de cálcio na dieta de frangos de corte

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