“…The extent of this increased incidence depends strongly on the particular drugs being taken ( Koro et al, 2002 ), indicating that antipsychotic medication, particularly with drugs that also induce weight gain, makes a substantial contribution to this relationship. Other consequences or correlates of schizophrenia, such as higher prevalence of smoking, less exercise, and poor diet, may also contribute to T2D risk, leading to the suggestion from Mizuki et al (2021) that “schizophrenia itself is a risk for increased onset of diabetes.” More difficult is determining whether there is an inherent association between schizophrenia and T2D independent of the consequences of psychotic symptoms and their treatment. The main approach is to search for T2D risk factors in early-stage, drug-naïve schizophrenia patients.…”