Mechanisms Underlying Selective Neuronal Tracking of Attended Speech at a “Cocktail Party”

Golumbic, Elana M. Zion; Ding, Nai; Bickel, Stephan; Lakatos, Péter L.; Schevon, Catherine A.; McKhann, Guy M.; Goodman, Robert; Emerson, Ronald G.; Mehta, Ashesh D.; Simon, Jonathan Z.; Poeppel, David; Schroeder, Charles E.

doi:10.1016/j.neuron.2012.12.037

Cited by 795 publications

(882 citation statements)

References 51 publications

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“…Attention has been demonstrated to increase activity in the auditory cortex 30,31 . Therefore, it might be argued that increased allocation of attention resources during active playing provides an alternative account to the enhanced fMRI signal in this condition compared with passive listening.…”

Section: Discussionmentioning

confidence: 99%

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds

et al. 2014

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Performing actions with auditory consequences modulates the response in auditory cortex to otherwise identical stimuli passively heard. Such modulation has been suggested to occur through a corollary discharge sent from the motor cortex during voluntary actions. However, the relationship between the effector used to generate the sound, type of modulation and changes in perceptual sensitivity are unclear. Here we use functional magnetic resonance imaging on healthy subjects and demonstrate bilateral enhancement in the auditory cortex to self-generated versus externally generated sounds. Furthermore, we find that this enhancement is stronger when the sound-producing hand is contralateral to the auditory cortex. At the behavioural level, binaural hearing thresholds are lower for self-generated sounds and monaural thresholds are lower for sounds triggered by the hand ipsilateral to the stimulated ear. Together with functional connectivity analysis, our results suggest that a corollary discharge sent from active motor cortex enhances activity in the auditory cortex and increases perceptual sensitivity in a lateralized manner.

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Section: Discussionmentioning

confidence: 99%

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds

et al. 2014

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“…We argue that high spectral resolution can support sound segregation and, as a result, selective attention can operate on the individually perceived auditory objects, enhancing the neural representation of the attended speech and suppressing the neural representation of unattended speech (Horton et al 2013;Kong et al 2014). The brain can do so by using temporal coherence to bind together acoustic features belonging to the same speech stream (Shamma et al 2011) or by predicting which moments contain more information about the attended speech than the competing speech (Schroeder et al 2008;Schroeder and Lakatos 2009;Zion-Golumbic et al 2013).…”

Section: Effect Of Spectral Degradation On Attentional Modulation Ofmentioning

confidence: 99%

Effects of Spectral Degradation on Attentional Modulation of Cortical Auditory Responses to Continuous Speech

Kong

Somarowthu

Ding

2015

JARO

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This study investigates the effect of spectral degradation on cortical speech encoding in complex auditory scenes. Young normal-hearing listeners were simultaneously presented with two speech streams and were instructed to attend to only one of them. The speech mixtures were subjected to noise-channel vocoding to preserve the temporal envelope and degrade the spectral information of speech. Each subject was tested with five spectral resolution conditions (unprocessed speech, 64-, 32-, 16-, and 8-channel vocoder conditions) and two target-to-masker ratio (TMR) conditions (3 and 0 dB). Ongoing electroencephalographic (EEG) responses and speech comprehension were measured in each spectral and TMR condition for each subject. Neural tracking of each speech stream was characterized by cross-correlating the EEG responses with the envelope of each of the simultaneous speech streams at different time lags. Results showed that spectral degradation and TMR both significantly influenced how top-down attention modulated the EEG responses to the attended and unattended speech. That is, the EEG responses to the attended and unattended speech streams differed more for the higher (unprocessed, 64 ch, and 32 ch) than the lower (16 and 8 ch) spectral resolution conditions, as well as for the higher (3 dB) than the lower TMR (0 dB) condition. The magnitude of differential neural modulation responses to the attended and unattended speech streams significantly correlated with speech comprehension scores. These results suggest that severe spectral degradation and low TMR hinder speech stream segregation, making it difficult to employ top-down attention to differentially process different speech streams.

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“…In healthy populations, attention to speech results in entrainment of the subject's evoked activity not only to low‐level features of the stimulus itself, but also the cortical activity of other subjects experiencing the same stimulus 18, 19, 20, 21. This effect has been observed in visual as well as auditory contexts for EEG,19, 20, 22 functional magnetic resonance imaging,23, 24 and magnetoencephalography 25, 26.…”

Section: Introductionmentioning

confidence: 96%

“…This effect has been observed in visual as well as auditory contexts for EEG,19, 20, 22 functional magnetic resonance imaging,23, 24 and magnetoencephalography 25, 26. Moreover, intersubject correlation (ISC) of EEG evoked responses has been shown to discriminate attention better than conventional EEG measures19 and is able to predict selective auditory attention during auditory stream segregation 27, 28. Through the use of narrative speech, our approach has the potential to capture sustained auditory attention, a prerequisite for comprehension of everyday speech.…”

Section: Introductionmentioning

confidence: 96%

Divergent neural responses to narrative speech in disorders of consciousness

Iotzov

Fidali

Petroni

et al. 2017

Ann Clin Transl Neurol

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ObjectiveClinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healthy controls.MethodsElectroencephalographic data were recorded from 20 subjects with disorders of consciousness and 14 healthy controls during of two narrative audio stimuli, presented both forwards and time‐reversed. Intersubject correlation of evoked electroencephalography signals were calculated, comparing responses of both groups to those of the healthy control subjects. This analysis was performed blinded and subsequently compared to the diagnostic status of each patient based on the Coma Recovery Scale‐Revised.ResultsSubjects with disorders of consciousness exhibit significantly lower intersubject correlation than healthy controls during narrative speech. Additionally, while healthy subjects had higher intersubject correlation values in forwards versus backwards presentation, neural responses did not vary significantly with the direction of playback in subjects with disorders of consciousness. Increased intersubject correlation values in the backward speech condition were noted with improving disorder of consciousness diagnosis, both in cross‐sectional analysis and in a subset of patients with longitudinal data.InterpretationIntersubject correlation of neural responses to narrative speech audition differentiates healthy controls from patients and appears to index clinical diagnoses in disorders of consciousness.

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Mechanisms Underlying Selective Neuronal Tracking of Attended Speech at a “Cocktail Party”

Cited by 795 publications

References 51 publications

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds

Lateralized enhancement of auditory cortex activity and increased sensitivity to self-generated sounds

Effects of Spectral Degradation on Attentional Modulation of Cortical Auditory Responses to Continuous Speech

Divergent neural responses to narrative speech in disorders of consciousness

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