Mechanisms underlying retardation of aging by dietary energy restriction

Shimokawa, Isao

doi:10.1111/pin.13387

Cited by 2 publications

(1 citation statement)

References 96 publications

(213 reference statements)

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“…The effects of CR have been extensively studied in terms of longevity, describing a species-and even a strain-dependent sexual dimorphism in rodents [38,39]. The mechanisms by which CR promotes longevity are the same as those that promote weight loss and increased insulin sensitivity, i.e., improved health [40][41][42]. In this regulation, sirtuins and AMPK play a relevant role as nutrient sensors that increase insulin sensitivity and lipid oxidation [42][43][44][45].…”

Section: Discussionmentioning

confidence: 99%

Sex-Dependent Metabolic Effects in Diet-Induced Obese Rats following Intermittent Fasting Compared with Continuous Food Restriction

Bosch de Basea,

Boguñà,

Sánchez

et al. 2024

Nutrients

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Recently, intermittent fasting has gained relevance as a strategy to lose weight and improve health as an alternative to continuous caloric restriction. However, the metabolic impact and the sex-related differences are not fully understood. The study aimed to compare the response to a continuous or intermittent caloric restriction in male and female rats following a previous induction of obesity through a cafeteria diet by assessing changes in body weight, energy intake, metabolic parameters, and gene expression in liver hepatic and adipose tissue. The continuous restriction reduced the energy available by 30% and the intermittent restriction consisted of a 75% energy reduction on two non-consecutive days per week. The interventions reduced body weight and body fat in both sexes, but the loss of WAT in females was more marked in both models of caloric restriction, continuous and intermittent. Both caloric restrictions improved insulin sensitivity, but more markedly in females, which showed a more pronounced decrease in HOMA-IR score and an upregulation of hepatic IRS2 and Sirt1 gene expression that was not observed in males. These findings suggest the fact that females are more sensitive than males to reduced caloric content in the diet.

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