Mechanisms regulating adrenomedullin gene expression in the left ventricle: role of mechanical load

Our previous study showed elevation of plasma adrenomedullin (ADM) during static handgrip in patients with heart failure (HF). It is hypothesized that ADM increases with left ventricle dysfunction during handgrip and thus plays a compensatory role. In the present study pre-ejection period (PEP) and left ventricular ejection time (LVET) were used to assess cardiac performance in 24 male HF patients (II/III class NYHA) during two 3-min bouts of handgrip at 30% of maximal voluntary contraction (MVC) performed alternately with each hand without any break between the bouts. Plasma ADM, noradrenaline (NA), adrenaline (A), heart rate (HR), blood pressure (BP) and stroke volume (SV) were determined. During handgrip plasma ADM, NA, A, HR, BP, PEP/LVET increased, PEP was prolonged and LVET shortened. The increases in plasma ADM correlated with changes in: PEP (r = -0.881), LVET (r = 0.713), PEP/LVET (r = -0.769), SV (r = 0.836), diastolic BP (r = 0.700), total peripheral resistance (TPR) (r = 0.718) and noradrenaline (r = 0.756). The study demonstrated that in HF patients changes in plasma ADM during handgrip are related to cardiac performance.

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“…, 1995; Øie et al. , 2000; Luodonpää et al. , 2003) have demonstrated the presence of ADM, its mRNA and specific receptors in the heart.…”

Section: Introductionmentioning

confidence: 99%

“…, 2002, 2004). Luodonpää et al. (2003) showed that cardiac ADM gene expression is upregulated in response to pressure overload.…”

Section: Introductionmentioning

confidence: 99%

Relationships between plasma adrenomedullin concentration and systolic time intervals during static handgrip in patients with heart failure

Krzemiński

Cybulski

Nazar

2009

Clin Physio Funct Imaging

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“…Each is released in the presence of cardiac volume overload and stretch (1)(2)(3)(4)(11)(12)(13). BNP, ANP, and ADM are each derived from larger precursor proteins and cleaved at the cell surface to produce an active peptide and, at least in the cases of BNP and ANP, a biologically inactive or less active amino-terminal fragment (N-terminal BNP, N-terminal ANP) (13).…”

Section: See Page 315mentioning

confidence: 99%