Mechanisms Regulating Abnormal Circular RNA Biogenesis in Cancer

Huang, Ying; Zhu, Qubo

doi:10.3390/cancers13164185

Cited by 37 publications

(30 citation statements)

References 80 publications

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“…The circRNAs play critical biological functions in eukaryotic organisms, which compete for miRNAs. By base-complementary pairing with the target mRNA 3-UTR, miRNAs can block the translation and stability of target RNA-binding Proteins (RBPs) can interact with circRNAs and regulate circRNA splicing, replication, folding, stabilization and localization ( Huang and Zhu 2021 ; Zeng et al, 2021 ). In summary, the circRNAs act as miRNA sponges and interact with RBPs to perform transcriptional functions in organisms.…”

Section: The Regulatory Mechanism Of Ncrnas In the Glycolysis Of Ovar...mentioning

confidence: 99%

Noncoding RNAs in the Glycolysis of Ovarian Cancer

Zhang

Liu

2022

Front. Pharmacol.

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Energy metabolism reprogramming is the characteristic feature of tumors. The tumorigenesis, metastasis, and drug resistance of ovarian cancer (OC) is dependent on energy metabolism. Even under adequate oxygen conditions, OC cells tend to convert glucose to lactate, and glycolysis can rapidly produce ATP to meet their metabolic energy needs. Non-coding RNAs (ncRNAs) interact directly with DNA, RNA, and proteins to function as an essential regulatory in gene expression and tumor pathology. Studies have shown that ncRNAs regulate the process of glycolysis by interacting with the predominant glycolysis enzyme and cellular signaling pathway, participating in tumorigenesis and progression. This review summarizes the mechanism of ncRNAs regulation in glycolysis in OC and investigates potential therapeutic targets.

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Section: The Regulatory Mechanism Of Ncrnas In the Glycolysis Of Ovar...mentioning

confidence: 99%

Noncoding RNAs in the Glycolysis of Ovarian Cancer

Zhang

Liu

2022

Front. Pharmacol.

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“…Conservative, circRNAs is highly conserved across species ( AbouHaidar et al, 2014 ; Mao et al, 2021 ; Meyer et al, 2021 ). Specificity, mainly in terms of cell type specificity and tissue specificity ( Shang et al, 2019 ; Gokool et al, 2020 ; Huang and Zhu, 2021 ).…”

Section: Biogenesis and Classification Of Circular Rnasmentioning

confidence: 99%

“…Circular RNAs (circRNAs) are covalently contiguous closed loops without 5′ and 3′ ends, and are structurally more stable than linear RNAs and less susceptible to degradation by nucleic acid exonucleases ( Jakobi and Dieterich, 2019 ; Huang and Zhu, 2021 ). Initially circRNAs were thought to be products of missplicing or intermediates escaping from the lasso structure of introns ( Chen and Huang, 2018 ; Tsitsipatis and Gorospe, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Research Progress of circRNAs in Glioblastoma

Guo

Piao

2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a class of single-stranded covalently closed non-coding RNAs without a 5′ cap structure or 3′ terminal poly (A) tail, which are expressed in a variety of tissues and cells with conserved, stable and specific characteristics. Glioblastoma (GBM) is the most aggressive and lethal tumor in the central nervous system, characterized by high recurrence and mortality rates. The specific expression of circRNAs in GBM has demonstrated their potential to become new biomarkers for the development of GBM. The specific expression of circRNAs in GBM has shown their potential as new biomarkers for GBM cell proliferation, apoptosis, migration and invasion, which provides new ideas for GBM treatment. In this paper, we will review the biological properties and functions of circRNAs and their biological roles and clinical applications in GBM.

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“…Circular RNAs (circRNAs)-a particular type of endogenous noncoding RNA-were first identified in viruses in the 1990s (8). Initially, circRNAs were considered to be the product of missplicing.…”

Section: Introductionmentioning

confidence: 99%

Systematic Review With Meta-Analysis: Diagnostic, Prognostic and Clinicopathological Significance of CircRNA Expression in Renal Cancer

et al. 2022

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BackgroundRenal cancer (RC) is one of the most common malignant tumors of the urinary system, and molecular targets for the specific diagnosis and treatment of RC have been widely explored. The purpose of this study was to systematically analyze circular RNAs (circRNAs), which may serve as novel tumor markers in terms of the diagnosis, prognosis and clinicopathological characteristics of RC.MethodsPubMed and Web of Science were systematically searched for literature as up to July 30, 2021. All included studies were evaluated by the evaluation system, and the results were satisfactory. Hazard ratios (HRs) and odds ratios (ORs) were used to assess the association of circRNAs with diagnostic and clinicopathological indicators. The sensitivity (SEN), specificity (SPE), positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio and area under the summary receiver operating characteristic curve (AUC) were combined to evaluate the diagnostic performance of circRNAs in RC.ResultsWe included 22 studies that met the criteria, including 18 that were prognostic, 4 that were diagnostic, and 12 that were clinicopathologically relevant. In terms of prognosis, we found that upregulated circRNAs were positively associated with poor overall survival in patients with RC (HR=1.63, 95% CI=1.43–1.85). In terms of diagnosis, the combined SEN, SPE and AUC of circRNAs in the diagnosis of RC were 0.82, 0.84 and 0.89 (0.86–0.91), respectively. In terms of clinicopathological features, upregulated circRNAs were associated with the Fuhrman grade (OR=0.641, 95% CI=0.471–0.873), T stage (OR=0.236, 95% CI=0.141–0.396), TNM stage (OR=0.225, 95% CI=0.158–0.321) and lymphatic metastasis (OR=0.329, 95% CI=0.193–0.560).ConclusionOur meta-analysis confirms that circRNAs may be candidate biomarkers for the diagnosis, prognosis, and clinicopathological indicators of RC.

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Mechanisms Regulating Abnormal Circular RNA Biogenesis in Cancer

Cited by 37 publications

References 80 publications

Noncoding RNAs in the Glycolysis of Ovarian Cancer

Noncoding RNAs in the Glycolysis of Ovarian Cancer

Research Progress of circRNAs in Glioblastoma

Systematic Review With Meta-Analysis: Diagnostic, Prognostic and Clinicopathological Significance of CircRNA Expression in Renal Cancer

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