Mechanisms of γδ T cell accumulation in visceral adipose tissue with aging
Sujata Mukherjee,
Maria E. C. Bruno,
Jason Oakes
et al.
Abstract:γδ T cells are resident in visceral adipose tissue (VAT) where they show an age-associated increase in numbers and contribute to local and systemic chronic inflammation. However, regulation of this population and mechanisms for the age-dependent accumulation are not known. In this study, we identified a progressive trend of γδ T cell accumulation in VAT over the lifespan in mice and explored physiological mechanisms contributing to accumulation. Using isochronic parabiotic pairs of wild-type (WT) and T cell re… Show more
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