Mechanisms of Yersinia enterocolitica Evasion of the Host Innate Immune Response by V Antigen

Th1-type immune response to infection by pYV-cured phoP-phoQ null mutant of Yersinia pseudotuberculosis is defective in mouse model

“…IL-10 is secreted by macrophages, B cells, and several subtypes of T cells such as Th2 or regulatory T cells, and has antiprotective role in yersiniosis (Bohn and Autenrieth 2004). LcrV is one of the antigens of Yersinia that is involved in upregulation of IL-10 (Sing et al 2002). In the present study, IL-10 production was observed in mice immunized with strain 1A and DPQ1A (Fig.…”

From the Th1/Th2 Paradigm towards a Toll-Like Receptor/T-Helper Bias

“…Ϫ/Ϫ mice are less susceptible to lethal infections with Yersinia enterocolitica or Candida albicans, and their resistance is mediated by a stronger Th1 response due to diminished production of IL-10 during infection (32,45). In the case of Candida infection, we have demonstrated that TLR2 signals induce proliferation and survival of CD4…”

“…In support of this observation are the data demonstrating that, whereas interaction of E. coli LPS with TLR4 induces production of IL-12p70, the recognition of P. gingivalis LPS by TLR2 is unable to induce IL-12p70 release and favors a Th2-type response (16,36). Consistent with a preferential role of TLR2 in the activation of Th2 responses, the TLR2 ligand Pam3Cys activates mainly Th2-type responses (11), whereas interaction of Yersinia enterocolitica V antigen or the phosphatidylserine from Schistosoma mansoni with TLR2 results in IL-10 release and induction of T-regulatory cells favoring a Th2 bias (45,52). These data demonstrate that signals mediated by various TLRs can induce specific cytokine profiles, with TLR4, TLR5, TLR9, and TLR3 inducing a Th1-type response and TLR2 inducing a skewing towards Th2 development (Fig.…”

Effect of rLcrV and rYopB from Yersinia pestis on murine peritoneal macrophages in vitro

“…Brubaker [40] in 2003 also supported the role of LcrV and other Yops in inhibition of innate immunity. Recently Sing et al [41] in 2003 further suggested a crucial role of LcrV in evasion of Y. enterocolitica. In the present investigation, it is suggested that IL-10 possibly play a role in the rLcrV and rYopB induced inhibition of LPS mediated production of TNF-␣ and other proinflammatary cytokines and chemokines in macrophages.…”