Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41
Thomas Bonacci,
Derek L Bolhuis,
Nicholas G Brown
et al.
Abstract:The ubiquitin-like protein ISG15 (interferon-stimulatedgene15) regulates the host response to bacterial and viral infections through its conjugation to proteins (ISGylation) following interferon production. ISGylation is antagonized by the highly specific cysteine protease USP18, which is the major deISGylating enzyme. However, mechanisms underlying USP18’s extraordinary specificity towards ISG15 remains elusive. Here, we show that USP18 interacts with its paralog USP41, whose catalytic domain shares 97% ident… Show more
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