Mechanisms of Traditional Chinese Medicine in the Treatment of Mammary Gland Hyperplasia

Li, Xiaoliang; Xin, Ping; Wang, Changfu; Wang, Zhibin; Wang, Qiuhong; Kuang, Hai‐Xue

doi:10.1142/s0192415x17500276

Cited by 51 publications

(31 citation statements)

References 19 publications

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“…Breast hyperplasia mainly occurs in middle-aged women, accounting for 70% of breast diseases [12], and greatly harming women's physical and mental health. In recent years, Juhe has been used to treat acute mastitis and breast hyperplasia, demonstrating signi cant effects [13,14]; thus, signi cant attention has been given to its medicinal value.…”

Section: Introductionmentioning

confidence: 99%

Assessing the equivalence between traditional medicinal varieties and nontraditional medicinal varieties of Citri reticulata Semen

Xian

Wang

et al. 2020

Preprint

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Background Juhe, which is derived from seeds of citrus (Citri reticulata Semen), is wildly used as a traditional Chinese medicine. Its original plants have numinous variety, and new varieties are constantly emerging, especially in recent years. The decline in the market share of traditional varieties each year, has resulted in a shortage of Juhe resources, and nontraditional Juhe varieties have been used clinically without research. Thus Juhe resources vary significantly. Furthermore, most of new varieties are hybrids, with significant differences in genes, active ingredients. Therefore, a further research is needed on Nontraditional medicinal varieties. Methods In this study, the genetic diversity, shape and size, and flavonoids content of 35 different batches of Juhe samples, from different source, were analyzed base on SRAP molecular markers, a stereo microscope, and HPLC. Then correlation analysis was performed using these data. Results The genetic backgrounds of traditional medicinal varieties (TMV) and nontraditional medicinal varieties (N-TMV) differed significantly, and TMV were closely related to some Citrus ‘Ponkan’ samples. Seeds of TMV and N-TMV differ based on shape, size and number. In addition, flavonoid compounds and level in the seeds of TMV and N-TMV also showed a significant difference. Five batches of C. reticulata ‘Ponkan’ samples collected from Zigong, Meishan, Neijiang, Nanchong and Jiangyou were closely related to the traditional medicinal variety Citrus reticulata ‘Dahongpao’,based on genetic relationship, shape and sizes, as well as flavonoids content. Conclusins: A total of 5 C. reticulata ‘Ponkan’ samples, including Zigong No. 7, Meishan No. 21, Neijiang No. 27, Nanchong No. 32, and Jiangyou No. 34, were closely related to the traditional medicinal variety C. reticulata ‘Dahongpao’ in genetic relationship, seeds’ characteristics and sizes, and flavonoids content. These varieties could serve as a new medicinal variety.

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Section: Introductionmentioning

confidence: 99%

Assessing the equivalence between traditional medicinal varieties and nontraditional medicinal varieties of Citri reticulata Semen

Xian

Wang

et al. 2020

Preprint

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“…Hyperplasia of mammary gland (HMG), a multi-factorial complicated disease, accounts for more than 70% of all breast disease that occurs frequently among middle-aged women and is highly associated with breast cancer 1 . Perhaps due to the quickening pace of life, with increasing work-related pressure, the prevalence of HMG is high in China 2 .…”

Section: Introductionmentioning

confidence: 99%

The potential interaction of hereditary and reproductive factors in the etiology of mammary gland hyperplasia: a case-control study

gao

Liu

Fan

et al. 2019

Preprint

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Background: Family history of breast cancer and female reproductive factors may work together to influence hyperplasia of mammary gland (HMG) risk. However, the association with HMG risk is poorly characterized and might be important to understand the causation of HMG.Methods: A total of 1881 newly diagnosed HMG cases and 1900 controls were recruited between 2012 and 2017. We collected each participant's demographic characteristics, female reproductive factors and family history of breast cancer. A multi-analytic strategy combining unconditional logistic regression, multifactor dimensionality reduction (MDR) and crossover approaches were applied to systematically identify the interactions of family history of breast cancer and reproductive factors on HMG susceptibility.Results: In MDR analysis, high-order interactions among education level, breastfeeding duration and family history of breast cancer were identified among women (OR=7.069, 95%CI: 6.080-8.219). Similarly, in crossover analysis, compared with individuals having low education level and no family history of breast cancer, HMG risk increased significantly for those having high education level and family history of breast cancer (OR=36.389, 95%CI: 11.469-115.451), similar additive interaction effect was observed among short breastfeeding duration women (OR=27.699, 95%CI: 3.730-205.699).Conclusion: This study suggests high-order interactions of high education level, short breastfeeding duration and family history of breast cancer may synergistically increased HMG risk.

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“…( Zhang et al, 2012 ). The morbidity of HMG has increased due to increased work-related stress and competitive career pressures along with the fast pace of modern life ( Li et al, 2017a ). However, there is still not a sufficient understanding of the etiology of HMG, and pertinent therapeutic strategies are limited.…”

Section: Introductionmentioning

confidence: 99%

The Modulatory Properties of Li-Ru-Kang Treatment on Hyperplasia of Mammary Glands Using an Integrated Approach

et al. 2018

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Background: Li-Ru-Kang (LRK) has been used in the treatment of hyperplasia of mammary glands (HMG) for several decades and can effectively improve clinical symptoms. This study aims to investigate the mechanism by which LRK intervenes in HMG based on an integrated approach that combines metabolomics and network pharmacology analyses.Methods: The effects of LRK on HMG induced by estrogen-progesterone in rats were evaluated by analyzing the morphological and pathological characteristics of breast tissues. Moreover, UPLC-QTOF/MS was performed to explore specific metabolites potentially affecting the pathological process of HMG and the effects of LRK. Pathway analysis was conducted with a combination of metabolomics and network pharmacology analyses to illustrate the pathways and network of LRK-treated HMG.Results: Li-Ru-Kang significantly improved the morphological and pathological characteristics of breast tissues. Metabolomics analyses showed that the therapeutic effect of LRK was mainly associated with the regulation of 10 metabolites, including prostaglandin E2, phosphatidylcholine, leukotriene B4, and phosphatidylserine. Pathway analysis indicated that the metabolites were related to arachidonic acid metabolism, glycerophospholipid metabolism and linoleic acid metabolism. Moreover, principal component analysis showed that the metabolites in the model group were clearly classified, whereas the metabolites in the LRK group were between those in the normal and model groups but closer to those in the normal group. This finding indicated that these metabolites may be responsible for the effects of LRK. The therapeutic effect of LRK on HMG was possibly related to the regulation of 10 specific metabolites. In addition, we further verified the expression of protein kinase C alpha (PKCα), a key target predicted by network pharmacology analysis, and showed that LRK could significantly improve the expression of PKCα.Conclusion: Our study successfully explained the modulatory properties of LRK treatment on HMG using metabolomics and network pharmacology analyses. This systematic method can provide methodological support for further understanding the complex mechanism underlying HMG and possible traditional Chinese medicine (TCM) active ingredients for the treatment of HMG.

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Mechanisms of Traditional Chinese Medicine in the Treatment of Mammary Gland Hyperplasia

Cited by 51 publications

References 19 publications

Assessing the equivalence between traditional medicinal varieties and nontraditional medicinal varieties of Citri reticulata Semen

Assessing the equivalence between traditional medicinal varieties and nontraditional medicinal varieties of Citri reticulata Semen

The potential interaction of hereditary and reproductive factors in the etiology of mammary gland hyperplasia: a case-control study

The Modulatory Properties of Li-Ru-Kang Treatment on Hyperplasia of Mammary Glands Using an Integrated Approach

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