Mechanisms of thrombocytopenia in patients with lymphoproliferative diseases

Kuznetsov, A. I.; Ivanov, A L; Idel'son, L I; Мазуров, А. В.

doi:10.1111/j.1600-0609.1992.tb00913.x

Cited by 16 publications

(3 citation statements)

References 13 publications

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“…A previous study reported that platelet antibody IgG (PA-IgG) levels were elevated in 46% of patients with lymphoproliferative disorders (25). There was a certain correlation between thrombocytopenia and the increase of PA-IgG levels in patients with ITP after resection (26).…”

Section: Discussionmentioning

confidence: 94%

Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report

Ren

Liu

et al. 2023

Oncol Lett

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The present study reports the case of a patient with diffuse large B-cell lymphoma (DLBCL) and monoclonal gammopathy (MG) secondary to immune thrombocytopenia purpura (ITP). The clinical diagnoses and investigations of this case are reported. To the best of our knowledge, this is the first study to report DLBCL and MG secondary to ITP. The patient presented with a rare constellation of diseases, which made the diagnosis and treatment difficult for the physicians. The patient was followed up for 10 years using the morphological examination of bone marrow cells after chemotherapy, and currently continues with follow-up examinations. Treatments and prognoses for ITP, DLBCL and MG are common. However, treatments and prognoses are unclear for patients with all three conditions. The different clinical manifestations and disease processes of DLBCL and MG secondary to ITP cause difficulties for physicians in terms of treatment and prognosis. The present case report describes the comprehensive evaluation, diagnosis and treatment of a patient with DLBCL and MG secondary to, and concurrent with, ITP.

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Section: Discussionmentioning

confidence: 94%

Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report

Ren

Liu

et al. 2023

Oncol Lett

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“…PA-IgG were measured in washed platelets (see above) as previously described [18]. PA-IgG were detected by binding of 125 I-labeled affinity purified goat antihuman IgG antibodies (IMTEK, Moscow, Russian Federation).…”

Section: Methodsmentioning

confidence: 99%

Relationships of Mean Platelet Volume and Plasma Thrombopoietin with Glycocalicin Levels in Thrombocytopenic Patients

et al. 2014

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Backgrounds/Aims: Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients. Methods: MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPT patients had PA-IgG <300% and glycocalicin <50% of control values. Results and Conclusions: MPV was higher in ITP than in HPT patients: 9.56 ± 1.69 and 7.59 ± 0.90 fl (p < 0.001). In the ITP group a direct correlation was detected between MPV and glycocalicin (r = 0.344, p < 0.001). This interaction was essentially expressed in patients with normal/increased glycocalicin (≥100% of control; r = 0.470, p < 0.001, n = 64). TPO was greatly enhanced in HPT in comparison with ITP patients (958 ± 659 and 11 ± 27 pg/ml, p < 0.001). In the ITP group a reverse correlation was detected between TPO and glycocalicin (r = -0.373, p = 0.006). © 2014 S. Karger AG, Basel

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“…Immune thrombocytopenia is often seen in patients with B‐cell lymphoproliferative disorders 20‐22 . Rather than specific autoantibody being produced by the monoclonal malignant population itself, it is more likely that the inherent immunomodulated state in these diseases allows the emergence of autoreactive clones 23 .…”

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confidence: 99%

Molecular characterization of the variable domains of an αIIbβ3‐specific immunoglobulin M κ platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between αIIbβ3 integrin antibodies

Jennings¹,

Harmer²,

Campbell

et al. 2007

Transfusion

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Mechanisms of thrombocytopenia in patients with lymphoproliferative diseases

Cited by 16 publications

References 13 publications

Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report

Diffuse large B‑cell lymphoma and monoclonal gammopathy secondary to immune thrombocytopenic purpura: A case report

Relationships of Mean Platelet Volume and Plasma Thrombopoietin with Glycocalicin Levels in Thrombocytopenic Patients

Molecular characterization of the variable domains of an αIIbβ3‐specific immunoglobulin M κ platelet cold agglutinin in a follicular lymphoma patient with treatment refractory autoimmune thrombocytopenia: idiotypic overlap between αIIbβ3 integrin antibodies

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