Mechanisms of the vasorelaxant effect of Danshen (Salvia miltiorrhiza) in rat knee joints

Cardiovascular effects of Danshen

“…Lam et al [83] investigated Danshen's dilating action on rat isolated femoral artery and found that the dilating action was mediated in part by the opening of tetraethylammonium-sensitive K + channels in the smooth muscle cells. The same investigators [84] more recently studied the mechanism of the vasorelaxant effect of Danshen in rat knee joints and found that the knee joint blood vessels are more sensitive to the relaxant effect of Danshen compared to blood vessels in the general circulation. They demonstrated that Danshen's vasorelaxant effect was partly mediated by a calcitonin gene-related peptide released from sensory nerves, and nitric oxide and prostaglandins also played a part [84].…”

“…The same investigators [84] more recently studied the mechanism of the vasorelaxant effect of Danshen in rat knee joints and found that the knee joint blood vessels are more sensitive to the relaxant effect of Danshen compared to blood vessels in the general circulation. They demonstrated that Danshen's vasorelaxant effect was partly mediated by a calcitonin gene-related peptide released from sensory nerves, and nitric oxide and prostaglandins also played a part [84]. Lam et al [83,84] found no evidence to support a role for muscarinic receptors, β-adrenoceptors or histamine receptors in either rat isolated femoral artery or rat knee joint blood vessels.…”

“…They demonstrated that Danshen's vasorelaxant effect was partly mediated by a calcitonin gene-related peptide released from sensory nerves, and nitric oxide and prostaglandins also played a part [84]. Lam et al [83,84] found no evidence to support a role for muscarinic receptors, β-adrenoceptors or histamine receptors in either rat isolated femoral artery or rat knee joint blood vessels.…”

Optimization of extraction and antioxidant activity of polysaccharides from Salvia miltiorrhiza Bunge residue

“…Danshen, the root of Salvia miltiorrhiza Bunge (Lamiaceae), is a well-known and very important traditional Chinese medicinal herb because of its use in treating cardiovascular and cerebrovascular diseases [1,2]. The liposoluble constituents, especially tanshinone I, tanshinone IIA, and cryptotanshinone, are considered to be the principal bioactive constituents of Danshen that contribute to its therapeutic effects [3].…”

Magnesium lithospermate B mediates anti-inflammation targeting activator protein-1 and nuclear factor-kappa B signaling pathways in human peripheral T lymphocytes

“…The most frequent clinical application of Danshen is for coronary artery disease [17][18][19]. In addition, Danshen has shown therapeutic effects in patients with hypertension, arrhythmia, stroke, peripheral vascular disease, and renal disease [20][21][22][23][24]. There are lipophilic and hydrophilic constituents in Danshen extracts.…”