Mechanisms of the pH dependent generation of hydroxyl radicals and oxygen induced by Ag nanoparticles

Multifunctional PLGA particles containing poly(l-glutamic acid)-capped silver nanoparticles and ascorbic acid with simultaneous antioxidative and prolonged antimicrobial activity

“…The capacity of nanoparticles to produce ROS is generally proposed to account for their toxicity [57], which has also been shown for AgNps [58]. In order to establish the influence of PLGA/AgNpP-GA/ascorbic acid particles on intracellular ROS formation, we measured the kinetics of their formation in HepG2 cells by the DCFH-DA assay.…”

Mechanism of pH-switchable peroxidase and catalase-like activities of gold, silver, platinum and palladium

“…The decomposition of H 2 O 2 is accompanied by the formation of OH radicals at lower pH conditions and O 2 at higher pH conditions, showing a pH-switchable peroxidase-like and catalase-like activities. When pH ¼ 7.4, these particles also present the SOD-like activity [11,12]. These functions, along with their good biocompatibility, have made Au and Ag NPs promising candidates for use in biosensors.…”

Biogenic synthesis of silver nanoparticles and their antioxidant and antibacterial activity

“…In the presence of hydrogen peroxide, the dispersed AgNPs can induce reactive oxygen species like hydroxyl radicals. Hydrogen peroxide inside a cell at a low dose can accelerate the dissolution of AgNPs and produce much stronger oxidative stress (He et al 2012). AgNPs can produce greater accounts of hydrogen peroxide and induce greater inflammasome formation because they can cause stronger leakage of cathepsins from impaired lysosomes and efflux of K ?…”