Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse

Xu, Zhe-Hao; Zhang, Jing-Cheng; Chen, Ke; Liu, Xuan; Li, Xian-Zhi; Yuan, Ming; Wang, Yue; Tian, Jing-Yu

doi:10.1016/j.ejphar.2023.176128

European Journal of Pharmacology

2023

DOI: 10.1016/j.ejphar.2023.176128

|View full text |Cite

Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse

Zhe-Hao Xu,

Jing-Cheng Zhang,

Ke Chen

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Pembrolizumab‐induced acquired perforating dermatosis

Gu,

de Silva,

Henderson

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

Immune checkpoint inhibitors such as the programmed cell death‐1 (PD‐1) inhibitors, pembrolizumab and nivolumab, are frontline treatments for several types of solid‐organ malignancies. However, cutaneous adverse effects with PD‐1 inhibitor therapy are common and include lichenoid reactions, eczema, vitiligo and bullous dermatoses. Perforating dermatosis is a rare condition characterised by the extrusion of degenerate materials from the upper dermis through the epidermis and has rarely been reported in association with PD‐1 inhibitor therapy. Herein, we report the first case to our knowledge of acquired perforating dermatosis following treatment with pembrolizumab.

show abstract

Pembrolizumab‐induced acquired perforating dermatosis

Gu,

de Silva,

Henderson

et al. 2024

JEADV Clinical Practice

View full text Add to dashboard Cite

show abstract

Cancer Therapy-induced Dermatotoxicity as a Window to Understanding Skin Immunity

Jiménez-Andrade,

Flesher,

Park

2024

Hematology/Oncology Clinics of North America

View full text Add to dashboard Cite

The regulation of the PD-1/PD-L1 pathway in imiquimod-induced chronic psoriasis itch and itch sensitization in mouse

Xu,

Wang,

Jiang

et al. 2024

Mol Pain

View full text Add to dashboard Cite

PD-1/PD-L1 inhibitors have been demonstrated to induce itch in both humans and experimental animals. However, whether the PD-1/PD-L1 pathway is involved in the regulation of chronic psoriatic itch remains unclear. This study aimed to investigate the role of the PD-1/PD-L1 pathway in imiquimod-induced chronic psoriatic itch. The intradermal injection of PD-L1 in the nape of neck significantly alleviated chronic psoriatic itch in imiquimod-treated skin. Additionally, we observed that spontaneous scratching behavior induced by imiquimod disappeared on day 21. Still, intradermal injection of PD-1/PD-L1 inhibitors could induce more spontaneous scratching for over a month, indicating that imiquimod-treated skin remained in an itch sensitization state after the spontaneous scratching behavior disappeared. During this period, there was a significant increase in PD-1 receptor expression in both the imiquimod-treated skin and the spinal dorsal horn in mice, accompanied by significant activation of microglia in the spinal dorsal horn. These findings suggest the potential involvement of the peripheral and central PD-1/PD-L1 pathways in regulating chronic itch and itch sensitization induced by imiquimod.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Mechanisms of the PD-1/PD-L1 pathway in itch: From acute itch model establishment to the role in chronic itch in mouse

Cited by 4 publications

References 54 publications

Pembrolizumab‐induced acquired perforating dermatosis

Pembrolizumab‐induced acquired perforating dermatosis

Cancer Therapy-induced Dermatotoxicity as a Window to Understanding Skin Immunity

The regulation of the PD-1/PD-L1 pathway in imiquimod-induced chronic psoriasis itch and itch sensitization in mouse

Contact Info

Product

Resources

About