Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis

Silveira, Kátia D.; Coelho, Fernanda; Vieira, Angélica T.; Barroso, Lívia Corrêa; Queiroz-Junior, Celso Martins; Costa, Vivian Vasconcelos; Sousa, Larissa F.C.; Oliveira, Marilene; Bäder, Michael; Silva, Tarcíla A.; Santos, Robson A.S.; Silva, Ana Cristina Simões e; Teixeira, Mauro Martins

doi:10.1016/j.peptides.2013.05.012

Cited by 74 publications

(61 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In line with previous data , preventive and therapeutic regimens with losartan improved the joint inflammatory signs induced by experimental AR in mice. They reduced the total number of leukocytes in the synovial cavity, the levels of NAG in periarticular tissues, the loss of proteoglycan in joint cartilage and the histological signs of inflammation, including cell infiltration, hyperplasia of the synovial membrane and hyperemia (Table , Fig.…”

Section: Resultssupporting

confidence: 91%

Protective effects of the angiotensin type 1 receptor antagonist losartan in infection‐induced and arthritis‐associated alveolar bone loss

Queiroz-Júnior

Silveira

Oliveira

et al. 2015

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

Section: Resultssupporting

confidence: 91%

Protective effects of the angiotensin type 1 receptor antagonist losartan in infection‐induced and arthritis‐associated alveolar bone loss

Queiroz-Júnior

Silveira

Oliveira

et al. 2015

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…In a small, randomized, double‐blind study of 11 patients, ACEIs with 10 mg/d ramipril for 8 weeks in addition to current anti‐inflammatory treatment markedly improved endothelial function and reduced plasma concentrations of TNF‐α and soluble CD40, although other inflammation parameters such as CRP, IL‐1, IL‐6, myeloperoxidase and erythrocyte sedimentation rate were not influenced . In vitro , captopril significantly suppressed TNF‐α and IL‐1 production in healthy human peripheral blood mononuclear cells stimulated by lipopolysaccharide .…”

Section: Ang II and Ramentioning

confidence: 98%

“…More recently, it was reported that losartan reduced local signs of inflammation (pain and oedema) and ameliorated histological joints changes both in murine AIA and rat AA. They observed that losartan decreased neutrophil recruitment, the production of TNF‐α, IL‐1β and chemokine (CXC motif) ligand 1, and directly inhibited leucocyte–endothelium interactions . Mackenzie et al .…”

Section: Ang II and Ramentioning

confidence: 99%

Angiotensin II in inflammation, immunity and rheumatoid arthritis

Cao

Wei

2015

Clinical and Experimental Immunology

101

View full text Add to dashboard Cite

SummaryRheumatoid arthritis (RA) is an autoimmune inflammatory disease that is characterized by increased cardiovascular morbidity and mortality, independent of the traditional risk factors for cardiovascular disease. Although classically known for its role in the regulation of circulatory homeostasis, angiotensin II (Ang II) is recognized to act as a powerful proinflammatory mediator. Some research has showed that Ang II plays important roles in autoimmune diseases, including RA, systemic lupus erythematosus and multiple sclerosis. Ang II blockers prove effective in reducing inflammation and autoimmunity in rheumatic diseases and their relative safety, together with their effects for reducing the cardiovascular disease risk, suggest that Ang II blockers may at least act as effective adjunctive therapy for disease control in patients with RA. The present review focuses systematically on the potential impact of Ang II and its receptors on inflammation and immunomodulation in patients with RA.

show abstract

“…Of intense interest is their anti-inflammatory action, and this action may be the rationale for their use by protecting organs like the heart and kidneys [26,27]. In an animal experiment,10mg/kg of Losartan decreased neutrophil migration, local cytokine production and leucocyte rolling and adhesion,thus ameliorating the local signs of inflammation in arthritis [28]. ARBs and ACEIs were also shown to decrease levels of IL-6, IL-8 and some other inflammatory cytokines [29,30,31].…”

Section: Discussionmentioning

confidence: 99%

The Effects of the Angiotensin Converting Enzyme Inhibitor Enalapril and the Angiotensin II Type 1 Receptor Blocker Losartan on Fracture Healing in Rats

Bayar¹,

Turan²,

Gülle³

et al. 2015

CIM

View full text Add to dashboard Cite

Purpose: Angiotensin converting enzyme inhibitors (ACEI) and type I angiotensin receptor blockers (ARB) have been shown to exert significant effects on bone tissue via a local renin-angiotensin-aldosterone system (RAS). Th e aim of our study was to delineate their influences on fracture healing process.Methods: Sixty adult male Wistar Albino rats were divided into three groups. After undergoing surgical femoral fracture and fi xation, the ACEI group received 10 mg/kg of Enalapril, the ARB group received 10 mg/kg of Losartan and the Control group did not receive any medication. Fracture healing was evaluated at second and fift h postoperative weeks by the Lane-Sandhu radiological staging system and by histological scoring system of Huoet al. ACE expression in fracture callus was studied by immunohistochemistry.Results: Both ACEI and ARB groups showed less fibrous tissue in the fracture area at the second week, but the histologic score differences were significant only between Control and ARB groups. At the fift h week, however, both radiological and histological scores for the ACEI group were significantly higher than both ARB and Control groups, while the scores for ARB and Control groups were similar. The presence of ACE expression in fracture callus was also observed. Conclusion:ACEIs had significant positive effects on fracture repair. Losartan failed to display these stimulatory effects, which suggests that local RAS in bone tissue exerts its actions via alternative receptors or pathways than the AT1 receptor.

show abstract

Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis

Cited by 74 publications

References 49 publications

Protective effects of the angiotensin type 1 receptor antagonist losartan in infection‐induced and arthritis‐associated alveolar bone loss

Protective effects of the angiotensin type 1 receptor antagonist losartan in infection‐induced and arthritis‐associated alveolar bone loss

Angiotensin II in inflammation, immunity and rheumatoid arthritis

The Effects of the Angiotensin Converting Enzyme Inhibitor Enalapril and the Angiotensin II Type 1 Receptor Blocker Losartan on Fracture Healing in Rats

Contact Info

Product

Resources

About