Mechanisms of T‐cell Lymphomagenesis

Lemonnier, François; Gaulard, Philippe; Leval, Laurence de

doi:10.1002/9781119671336.ch2

“…Plants utilize a strategy of activation, followed by a subsequent reduction for the synthesis of sugars, which are aldehydes, as energy sources and structural building blocks. In detail, the Calvin cycle is a series of biochemical reactions, [23–25] in which the carboxylic acid phosphoglyceric acid (PGA) that results from the insertion of CO 2 into ribulose 1,5‐biphosphate (RuBP) is activated to the phosphate ester bisphosphoglycerate (BPG) before being reduced to an aldehyde, glyceraldehyde‐3‐phosphate (G3P). The highly reactive G3P then undergoes condensation to form fructose or to regenerate RuBP.…”

Section: Introductionmentioning

confidence: 99%

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Bin Yeo,

Ho Jang,

In Jo

et al. 2023

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Utilizing CO2‐derived formaldehyde derivatives for fuel additive or polymer synthesis is a promising approach to reduce net carbon dioxide emissions. Existing methodologies involve converting CO2 to methanol by thermal hydrogenation, followed by electrochemical or thermochemical oxidation to produce formaldehyde. Adding to the conventional methanol oxidation pathway, we propose a new electrochemical approach to simultaneously generate formaldehyde derivatives at both electrodes by partial methanol oxidation and the direct reduction of CO2. To achieve this, a method to directly reduce CO2 to formaldehyde at the cathode is required. Still, it has been scarcely reported previously due to the acidity of the formic acid intermediate and the facile over‐reduction of formaldehyde to methanol. By enabling the activation and subsequent stabilization of formic acid and formaldehyde respectively in methanol solvent, we were able to implement a strategy where formaldehyde derivatives were generated at the cathode alongside the anode. Further mechanism studies revealed that protons supplied from the anodic reaction contribute to the activation of formic acid and the stabilization of the formaldehyde product. Additionally, it was found that the cathodic formaldehyde derivative Faradaic efficiency can be further increased through prolonged electrolysis time up to 50 % along with a maximum anodic formaldehyde derivative Faradaic efficiency of 90 %.

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Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Bin Yeo,

Ho Jang,

In Jo

et al. 2023

Angewandte Chemie

0

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Utilizing CO2‐derived formaldehyde derivatives for fuel additive or polymer synthesis is a promising approach to reduce net carbon dioxide emissions. Existing methodologies involve converting CO2 to methanol by thermal hydrogenation, followed by electrochemical or thermochemical oxidation to produce formaldehyde. Adding to the conventional methanol oxidation pathway, we propose a new electrochemical approach to simultaneously generate formaldehyde derivatives at both electrodes by partial methanol oxidation and the direct reduction of CO2. To achieve this, a method to directly reduce CO2 to formaldehyde at the cathode is required. Still, it has been scarcely reported previously due to the acidity of the formic acid intermediate and the facile over‐reduction of formaldehyde to methanol. By enabling the activation and subsequent stabilization of formic acid and formaldehyde respectively in methanol solvent, we were able to implement a strategy where formaldehyde derivatives were generated at the cathode alongside the anode. Further mechanism studies revealed that protons supplied from the anodic reaction contribute to the activation of formic acid and the stabilization of the formaldehyde product. Additionally, it was found that the cathodic formaldehyde derivative Faradaic efficiency can be further increased through prolonged electrolysis time up to 50 % along with a maximum anodic formaldehyde derivative Faradaic efficiency of 90 %.

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The Fate(s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy

Abou-el-Enein

2024

Blood Cancer Discovery

0

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The introduction of Chimeric Antigen Receptor (CAR) T-cell therapy represents a landmark advancement in treating resistant forms of cancer such as leukemia, lymphoma, and myeloma. However, concerns about long-term safety have emerged following an FDA investigation into reports of second primary malignancies (SPM) after CAR-T cell treatment. This review offers a thorough examination of how genetically modified T-cells might transform into CAR+ SPM. It explores genetic and molecular pathways leading to T-cell lymphomagenesis, the balance between CAR T-cell persistence, stemness, and oncogenic risk, and the trade-off of T-cell exhaustion, which may limit therapy efficacy but potentially reduce lymphomagenesis risk.

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Mechanisms of T‐cell Lymphomagenesis

Cited by 3 publications

References 120 publications

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

The Fate(s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy

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Mechanisms of T‐cell Lymphomagenesis

Cited by 3 publications

References 120 publications

Paired Electrosynthesis of Formaldehyde Derivatives from CO2 Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO2 Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO2 Reduction and Methanol Oxidation

The Fate(s) of CAR T-Cell Therapy: Navigating the Risks of CAR+ T-Cell Malignancy

Contact Info

Product

Resources

About

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation

Paired Electrosynthesis of Formaldehyde Derivatives from CO₂ Reduction and Methanol Oxidation