Mechanisms of T cell evasion by Epstein-Barr virus and implications for tumor survival
D. G. Sausen,
M. C. Poirier,
L. M. Spiers
et al.
Abstract:Epstein-Barr virus (EBV) is a prevalent oncogenic virus estimated to infect greater than 90% of the world’s population. Following initial infection, it establishes latency in host B cells. EBV has developed a multitude of techniques to avoid detection by the host immune system and establish lifelong infection. T cells, as important contributors to cell-mediated immunity, make an attractive target for these immunoevasive strategies. Indeed, EBV has evolved numerous mechanisms to modulate T cell responses. For e… Show more
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