Mechanisms of Staphylococcus aureus antibiotics resistance revealed by adaptive laboratory evolution
Shiwei Ma,
Yufan Xu,
Dan Luo
et al.
Abstract:Infection caused by drug-resistant Staphylococcus aureus is a rapidly developing public health and veterinary concern. Lack of a comprehensive understanding of the mechanisms underlying the emergence of drug-resistant strains, it makes S. aureus one of the most intractable pathogenic bacteria. To identify mutations that confer resistance to anti-S.aureus drugs, we established a laboratory-based adaptive evolution system and performed 10 rounds of evolution experiments against 15 clinically used antibiotics. We… Show more
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