Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster

Dove, Abigail; Cook, Brianne L.; Irgebay, Zhazira; Vecsey, Christopher G.

doi:10.1016/j.physbeh.2017.08.020

Cited by 14 publications

(24 citation statements)

References 91 publications

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“…3B) and the strong increase in micro-movements (Fig. 3C) are likely to represent an increase in food intake and egg-laying activity and may explain why such a strong decline in sleep amount was never identified using different tools (27,43,44). Interestingly, four-dimensional behavioural fingerprinting showed that the short sleep phenotype observed upon mating is qualitatively different from the one observed as natural variation in the CantonS population ( …”

Section: Qualitatively Different Types Of Short Sleeping Femalesmentioning

confidence: 94%

Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

Geissmann

Beckwith

Gilestro

2018

Preprint

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Sleep appears to be a universally conserved phenomenon among the animal kingdom but whether this striking evolutionary conservation underlies a basic vital function is still an open question.Using novel technologies, we conducted an unprecedentedly detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a life-long chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type Drosophila melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. We propose a three-partite model framework of sleep function, according to which, total sleep accounts for three components: a vital component, a useful component, and an accessory component.

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Section: Qualitatively Different Types Of Short Sleeping Femalesmentioning

confidence: 94%

Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

Geissmann

Beckwith

Gilestro

2018

Preprint

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“…A growing number of studies indicate that sleep regulatory mechanisms are plastic and can be harnessed to match an individual's sleep need with environmental demands 6,14,39 . Although Hebbian and synaptic plasticity modulate circuit function in a variety of contexts, these forms of plasticity may not be well suited to sculpt the balance of sleep and wakepromoting circuits at specific times of day 40 .…”

Section: Discussionmentioning

confidence: 99%

“…Although total sleep deprivation is the most common method for increasing sleep-drive in the laboratory, it seems unlikely that circumstances in the natural environment would keep an animal awake continuously for 12 h or more. In contrast, sleep consolidation is more easily disrupted and, perhaps, more likely to be impacted by a variety of environmental conditions 6,8 . Thus, we hypothesized that interrupting sleep consolidation would be sufficient to respecify the PDFR in the lLNvs.…”

Section: Respecification Of Pdfr In Llnvs Modulates Adult Behaviormentioning

confidence: 99%

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Sleep-drive reprograms clock neuronal identity through CREB-binding protein induced PDFR expression

Klose

Shaw

2019

Preprint

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Neuronal circuits can be re-modeled by Hebbian plasticity, synaptic scaling and, under some circumstances, activity-dependent respecification of cell-surface receptors. Although the impact of sleep on Hebbian plasticity and synaptic scaling are well studied, sleep's role in receptor respecification remains unclear. We demonstrate that high sleep-pressure quickly reprograms the Drosophila wake-promoting large-ventrolateral clock-neurons to express the Pigment Dispersing Factor receptor. The addition of this signaling input into the circuit is associated with increased waking and early mating success. The respecification of Pigment Dispersing Factor receptor in both young and adult large ventrolateral neurons requires two dopamine receptors and activation of the transcriptional regulator nejire (CREB-binding protein). These data identify receptor-respecification as an important mechanism to sculpt circuit function to match sleep levels with demand.

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“…These signaling pathway interactions are also important for the female post-mating response (PMR), which includes increased egg laying (Chen et al 1988) and feeding (Carvalho et al 2006), a preference for both yeast and salt instead of carbohydrates (Ribeiro and Dickson 2010;Vargas et al 2010;Walker et al 2015), decreased intestinal transit (Cognigni et al 2011;Apger-Mcglaughon and Wolfner 2013), decreased receptivity to mating (Manning 1962;Chen et al 1988;Aigaki et al 1991;Chapman et al 2003), decreased daytime sleep (Isaac et al 2010;Garbe et al 2016;Dove et al 2017) and lowered immune response (Fedorka et al 2007;Short and Lazzaro 2010;Short et al 2012). During copulation, peptides are transferred to the female in the male seminal fluid that induce the PMR (reviewed in Wolfner 1997;Wolfner 2002;Avila et al 2011;Sirot et al 2014).…”

mentioning

confidence: 99%

The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions

Newell

Ray

Dalton

et al. 2020

G3 Genes|Genomes|Genetics

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Examining cross-tissue interactions is important for understanding physiology and homeostasis. In animals, the female gonad produces signaling molecules that act distally. We examine gene expression in Drosophila melanogaster female head tissues in 1) virgins without a germline compared to virgins with a germline, 2) post-mated females with and without a germline compared to virgins, and 3) post-mated females mated to males with and without a germline compared to virgins. In virgins, the absence of a female germline results in expression changes in genes with known roles in nutrient homeostasis. At one-and three-day(s) post-mating, genes that change expression are enriched with those that function in metabolic pathways, in all conditions. We systematically examine female post-mating impacts on sleep, food preference and re-mating, in the strains and time points used for gene expression analyses and compare to published studies. We show that post-mating, gene expression changes vary by strain, prompting us to examine variation in female re-mating. We perform a genome-wide association study that identifies several DNA polymorphisms, including four in/near Wnt signaling pathway genes. Together, these data reveal how gene expression and behavior in females are influenced by cross-tissue interactions, by examining the impact of mating, fertility, and genotype.

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Mechanisms of sleep plasticity due to sexual experience in Drosophila melanogaster

Cited by 14 publications

References 91 publications

Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

Most sleep does not serve a vital function. Evidence from Drosophila melanogaster

Sleep-drive reprograms clock neuronal identity through CREB-binding protein induced PDFR expression

The Drosophila Post-mating Response: Gene Expression and Behavioral Changes Reveal Perdurance and Variation in Cross-Tissue Interactions

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