Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets

Yoshimoto, Yuki; Oishi, Yumiko

doi:10.1016/j.pharmthera.2023.108357

Cited by 5 publications

(2 citation statements)

References 214 publications

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“…This can not only prevent the onset of sarcopenia, but also accelerate muscle growth and repair, and ultimately enhance the overall muscle quality and body function. Skeletal muscle, as the most important exercise organ of the human body, assist in storing protein, regulating glucose metabolism and stabilizing blood sugar level, contributing to overall health of the body ( 81 , 104 , 105 ).…”

Section: Comprehensive Treatment Strategiesmentioning

confidence: 99%

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

Hou,

Xiang,

Wang

et al. 2024

Front. Endocrinol.

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Sarcopenia and diabetes are two age-related diseases that are common in the elderly population, and have a serious effect on their general health and quality of life. Sarcopenia refers to the progressive loss of muscle mass, strength and function, whereas diabetes is a chronic disease characterized by elevated blood sugar levels. The comorbidity of sarcopenia and diabetes is particularly concerning, as people with diabetes have a higher risk of developing sarcopenia due to the combination of insulin resistance, chronic inflammation and reduced physical activity. In contrast, sarcopenia destroyed blood sugar control and exacerbated the development of people with diabetes, leading to the occurrence of a variety of complications. Fortunately, there are a number of effective treatment strategies for sarcopenia in people with diabetes. Physical exercise and a balanced diet with enough protein and nutrients have been proved to enhance the muscular quality and strength of this population. Additionally, pharmacological therapies and lifestyle changes can optimize blood sugar control, which can prevent further muscle loss and improve overall health outcomes. This review aims to summarize the pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes, which help healthcare professionals recognize their intimate connection and provide a new vision for the treatment of diabetes and its complications in this population. Through early identification and comprehensive treatment, it is possible to improve the muscle function and general quality of life of elderly with diabetes and sarcopenia.

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Section: Comprehensive Treatment Strategiesmentioning

confidence: 99%

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

Hou,

Xiang,

Wang

et al. 2024

Front. Endocrinol.

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show abstract

“…Since obesity is a risk factor for T2DM, it is expected that a significant number of obese patients with T2DM also have sarcopenic obesity ( 106 ). It is likely that skeletal muscle mass and function relies on muscle progenitor cells cascade including satellite cells, interstitial progenitor cells and hence discovery of novel therapeutic targets to improve muscle mass and function are of utmost importance ( 107 ). Although the mechanism leading to impairment of muscle dysfunction in obesity remains unclear, the proinflammatory cytokines present in the muscles such TNFα, IL-6 which are elevated in obesity has been found to be reduced by exercise ( 108 ).…”

Section: Introductionmentioning

confidence: 99%

The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

Bathina

Armamento-Villareal

2023

Front. Endocrinol.

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Fractures associated with Type2 diabetes (T2DM) are major public health concerns in an increasingly obese and aging population. Patients with obesity or T2DM have normal or better than normal bone mineral density but at an increased risk for fractures. Hence it is crucial to understand the pathophysiology and mechanism of how T2DM and obesity result in altered bone physiology leading to increased fracture risk. Although enhanced osteoclast mediated bone resorption has been reported for these patients, the most notable observation among patients with T2DM is the reduction in bone formation from mostly dysfunction in osteoblast differentiation and survival. Studies have shown that obesity and T2DM are associated with increased adipogenesis which is most likely at the expense of reduced osteogenesis and myogenesis considering that adipocytes, osteoblasts, and myoblasts originate from the same progenitor cells. Furthermore, emerging data point to an inter-relationship between bone and metabolic homeostasis suggesting that these physiologic processes could be under the control of common regulatory pathways. Thus, this review aims to explore the complex mechanisms involved in lineage differentiation and their effect on bone pathophysiology in patients with obesity and T2DM along with an examination of potential novel pharmacological targets or a re-evaluation of existing drugs to improve bone homeostasis.

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An unusual configuration of two anomalies in the extensor digitorum profundus complex in a human

Okazaki,

Hamasaki,

Koyama

et al. 2024

Anat Sci Int

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Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targets

Cited by 5 publications

References 214 publications

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

Pathogenesis and comprehensive treatment strategies of sarcopenia in elderly patients with type 2 diabetes mellitus

The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis

An unusual configuration of two anomalies in the extensor digitorum profundus complex in a human

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