Mechanisms of sickness-induced decreases in food-motivated behavior

Kent, Stephen; Bret-Dibat, Jean Luc; Kelley, Keith W.; Dantzer, Robert

doi:10.1016/0149-7634(95)00037-f

Cited by 158 publications

(66 citation statements)

References 27 publications

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“…Current findings thus support the association of mutation status with depression but do not rule out an association of mutation status with the induction of sickness behavior. Future work should test the role of TGF-␣ in concert with inflammatory cytokines that have been implicated in sickness behavior [45][46][47].…”

Section: Discussionmentioning

confidence: 99%

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Pirl¹,

Traeger²,

Greer³

et al. 2011

The Oncologist

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Introduction. Depression appears to be associated with worse survival from cancer, but underlying mechanisms for this association are unknown. In the present study, we explored the degree to which tumor genotype may be associated with depression in patients with non-small cell lung cancer (NSCLC). We examined differences in depression severity and rates of positive screens for major depressive disorder among newly diagnosed patients with stage IV NSCLC and known epidermal growth factor receptor (EGFR) genotype.Methods. Newly diagnosed patients (n ‫؍‬ 53) with metastatic NSCLC attending an initial thoracic oncology consultation completed self-report questionnaires regarding demographics, smoking behavior, and depression before meeting with their oncologist. Biopsy samples were subsequently genotyped, including screening for EGFR mutations. We conducted a retrospective chart review to obtain clinical data, in-

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Section: Discussionmentioning

confidence: 99%

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Pirl¹,

Traeger²,

Greer³

et al. 2011

The Oncologist

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“…Although peripheral IL-1β and IL-6 responses to LPS did not differ between LD and SD rats, plasma TNFα concentrations were approximately two-fold higher in LD relative to SD rats 2 h after LPS treatment, matching the time course of the onset of exacerbated sickness behaviors in LD rats. Systemic administration of TNFα decreases social exploration in rats and mice (Bluthe et al, 1992;Bluthe et al, 1994) and is also sufficient to suppress feeding behavior under various paradigms (Kent et al, 1996;Plata-Salaman, 1999). TNFα, acting through the TNFR1 and TNFR2 receptor subtypes (Simen et al, 2006), is an important mediator of changes in ingestive behavior and behavioral depression that contribute to pathophysiology of LPS-induced sickness behavior .…”

Section: Discussionmentioning

confidence: 99%

Winter day lengths enhance T lymphocyte phenotypes, inhibit cytokine responses, and attenuate behavioral symptoms of infection in laboratory rats

Prendergast¹,

Kampf-Lassin²,

Yee³

et al. 2007

Brain, Behavior, and Immunity

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Annual variations in day length (photoperiod) trigger changes in the immune and reproductive system of seasonally-breeding animals. The purpose of this study was to determine whether photoperiodic changes in immunity depend on concurrent photoperiodic responses in the reproductive system, or whether immunological responses to photoperiod occur independent of reproductive responses. Here we report photoperiodic changes in enumerative, functional, and behavioral aspects of the immune system, and in immunomodulatory glucocorticoid secretion, in reproductively non-photoperiodic Wistar rats. T-cell numbers (CD3+, CD8+, CD8+CD25+, CD4+CD25+) were higher in the blood of rats housed in short as opposed to long day lengths for 10 weeks. Following a simulated bacterial infection (E. coli LPS; 125 μg/kg) the severity of several acute-phase sickness behaviors (anorexia, cachexia, neophobia, and social withdrawal) were attenuated in short days. LPS-stimulated IL-1β and IL-6 production were comparable between photoperiods, but plasma TNFα was higher in longday relative to short-day rats. In addition, corticosterone concentrations were higher in short-day relative to long-day rats. The data are consistent with the hypothesis that photoperiodic regulation of the immune system can occur entirely independently of photoperiodic regulation of the reproductive system. In the absence of concurrent reproductive responses, short days increase the numbers of leukocytes capable of immunosurveillance and inhibition of inflammatory responses, increase proinflammatory cytokine production, increase immunomodulatory glucocorticoid secretion, and ultimately attenuate behavioral responses to infection. Seasonal changes in the host immune system, endocrine system, and behavior may contribute to the seasonal variability in disease outcomes, even in reproductively non-photoperiodic mammals.

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“…Likewise, serum levels of proinflammatory interleukins IL-1b, IL-6, and TNF-a are elevated in depressed patients (Maes, 1999;Tuglu et al, 2003). Conversely, therapeutic treatments with proinflammatory cytokines result in 'sickness behavior' that is similar in many respects to depression, with decreased appetite, anorexia, weight loss, fatigue, loss of libido, sleep disturbances, and reduced social contact (Kent et al, 1996;Yirmiya et al, 2000;Dantzer, 2001), and depression is frequently observed in association with peripheral inflammatory cytokine activation in a number of medical conditions including viral infections, rheumatoid arthritis, cancer, and neurodegenerative diseases (Meijer et al, 1988;Hall and Smith, 1996;Yirmiya et al, 1999;Pollak et al, 2000). Additionally, in human volunteers, depression, anxiety, and memory impairment are associated with immune activation by the bacterial endotoxin, lipopolysaccharide, and are correlated with serum IL-1b and TNF-a levels induced by that treatment (Yirmiya et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters

Zhu

Blakely

Hewlett

2006

Neuropsychopharmacol

476

317

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Proinflammatory cytokines and serotonergic homeostasis have both been implicated in the pathophysiology of major psychiatric disorders. We have demonstrated that activation of p38 mitogen-activated protein kinase (MAPK) induces a catalytic activation of the serotonin transporter (SERT) arising from a reduction in the SERT K m for 5-hydroxytryptamine (5-HT). As inflammatory cytokines can activate p38 MAPK, we hypothesized that they might also activate neuronal SERT. Indeed, Interleukin-1beta (IL-1b) and tumor necrosis factor alpha (TNF-a) stimulated serotonin uptake in both the rat embryonic raphe cell line, RN46A, and in mouse midbrain and striatal synaptosomes. In RN46A cells, IL-1b stimulated 5-HT uptake in a dose-and time-dependent manner, peaking in 20 min at 100 ng/ml. This was abolished by IL-1ra (20 ng/ml), an antagonist of the IL-1 receptor, and by SB203580 (5 mM), a p38 MAPK inhibitor. TNF-a also dose-and time-dependently stimulated 5-HT uptake that was only partially blocked by SB203580. Western blots showed that IL-1b and TNF-a activated p38 MAPK, in an SB203580-sensitive manner. IL-1b induced an SB203580-sensitive decrease in 5-HT K m with no significant change in V max . In contrast, TNF-a stimulation decreased 5-HT K m and increased SERT V max . SB203580 selectively blocked the TNF-a-induced change in SERT K m . In mouse midbrain and striatal synaptosomes, maximal stimulatory effects on 5-HT uptake occurred at lower concentrations (IL-1b, 10 ng/ml; TNF-a, 20 ng/ml), and over shorter incubation times (10 min). As with RN46A cells, the effects of IL-1b and TNF-a were completely (IL-1b) or partially (TNF-a) blocked by SB203580. These results provide the first evidence that proinflammatory cytokines can acutely regulate neuronal SERT activity via p38 MAPK-linked pathways.

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Mechanisms of sickness-induced decreases in food-motivated behavior

Cited by 158 publications

References 27 publications

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Tumor Epidermal Growth Factor Receptor Genotype and Depression in Stage IV Non-Small Cell Lung Cancer

Winter day lengths enhance T lymphocyte phenotypes, inhibit cytokine responses, and attenuate behavioral symptoms of infection in laboratory rats

The Proinflammatory Cytokines Interleukin-1beta and Tumor Necrosis Factor-Alpha Activate Serotonin Transporters

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