“…Neuroscience aims to explain macroscopic behavior based on the microscopic operation of distinct neural circuits, and this requires carefully designed tasks that expose the relationship between the two. In the case of the antisaccade task (Coe and Munoz, 2017; Munoz and Everling, 2004), in which participants are instructed to withhold responding to a salient visual stimulus in favor of programming a saccade to a diametrically opposed location, performance relies heavily on frontal cortical mechanisms associated with cognitive control (Guitton et al, 1985; Everling and Fischer, 1998; Munoz and Everling, 2004; Condy et al, 2007; Luna et al, 2008; Hakvoort et al, 2012). The paradigm is considered to be a sensitive assay of impulsivity and executive function in general, and indeed, the mean reaction time ( RT ) and overall error rate in the antisaccade task are frequently used as biomarkers for cognitive development (Klein and Foerster, 2001; Luna et al, 2008; Coe and Munoz, 2017) and, in clinical settings, for mental dysfunction (Everling and Fischer, 1998; Munoz et al, 2003; Hutton and Ettinger, 2006; Antoniades et al, 2015; Wiecki et al, 2016).…”