Mechanisms of resistance of whole cells to toxic organic solvents

Heipieper, Hermann J.; Weber, F.J.; Sikkema, J.; Keweloh, Heribert; Bont, J.A.M. de

doi:10.1016/0167-7799(94)90029-9

Cited by 450 publications

(293 citation statements)

References 26 publications

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“…Other phenols, including vanillin, vanillic acid, hydroxybenzaldehyde, syringaldehyde, catechol, resorcinol, and salicylic acid have also been studied (as cited in Palmqvist and Hahn-Hä gerdal 2000). These compounds are toxic (Buchert et al 1989) because they compromise the integrity of biological membranes (Heipieper et al 1994). …”

Section: Common Inhibitors In Hydrolysates Effects and Mechanismsmentioning

confidence: 99%

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

Maris

Abbott

Bellissimi

et al. 2006

Antonie van Leeuwenhoek

429

276

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Fuel ethanol production from plant biomass hydrolysates by Saccharomyces cerevisiae is of great economic and environmental significance. This paper reviews the current status with respect to alcoholic fermentation of the main plant biomass-derived monosaccharides by this yeast. Wild-type S. cerevisiae strains readily ferment glucose, mannose and fructose via the Embden-Meyerhof pathway of glycolysis, while galactose is fermented via the Leloir pathway. Construction of yeast strains that efficiently convert other potentially fermentable substrates in plant biomass hydrolysates into ethanol is a major challenge in metabolic engineering. The most abundant of these compounds is xylose. Recent metabolic and evolutionary engineering studies on S. cerevisiae strains that express a fungal xylose isomerase have enabled the rapid and efficient anaerobic fermentation of this pentose.L-Arabinose fermentation, based on the expression of a prokaryotic pathway in S. cerevisiae, has also been established, but needs further optimization before it can be considered for industrial implementation. In addition to these already investigated strategies, possible approaches for metabolic engineering of galacturonic acid and rhamnose fermentation by S. cerevisiae are discussed. An emerging and major challenge is to achieve the rapid transition from proof-of-principle experiments under 'academic' conditions (synthetic media, single substrates or simple substrate mixtures, absence of toxic inhibitors) towards efficient conversion of complex industrial substrate mixtures that contain synergistically acting inhibitors.

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Section: Common Inhibitors In Hydrolysates Effects and Mechanismsmentioning

confidence: 99%

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

Maris

Abbott

Bellissimi

et al. 2006

Antonie van Leeuwenhoek

429

276

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“…Fatty acids are the major constituent of membrane phospholipids. The alterations of type and amount of these membrane structures are necessary to adapt to pollutants' impact (Heipieper et al 1994). Aromatic compounds, such as phenol, benzene and catechol increase membrane fluidity.…”

Section: Introductionmentioning

confidence: 99%

The adaptation responses of bacterial cytoplasmic membrane fluidity in the presence of environmental stress factors — polychlorinated biphenyls and 3-chlorobenzoic acid

et al. 2014

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Only bacteria sufficiently resistant to the toxic compounds in their environment can be used for the efficient biodegradation process in order to eliminate a widespread contamination by polychlorinated biphenyls (PCBs). The presence of PCBs results in bacterial controlled rigidification of cytoplasmic membrane. The four bacterial isolates from long-term PCB-contaminated soil (Alcaligenes xylosoxidans, Pseudomonas stutzeri) and sediment (Ochrobactrum anthropi, Pseudomonas veronii) have been used to select the strain most adapted to the PCBs, i.e. with efficient changes in the membrane phospholipid fatty acids. PCBs and their toxic degradation products -the 3-chlorobenzoic acids (3-CBA as the most toxic one) -were added separately to the liquid medium with glucose in two experimental sets: at lag phase and in stationary phase of bacterial growth in order to evaluate the effects of chemicals to cytoplasmic membrane. The main parameter -the changes in fatty acids composition (in the total lipids and the main membrane phospholipid phosphatidyletanolamine) were studied. 3-CBA caused growth inhibition when added at lag phase. However, when added during the stationary growth, inhibition was not observed. Similarly, after addition of PCBs to the stationary growth culture, inhibition of growth was not observed with all tested strains (except for P. stutzeri). This fact indicates the importance of time contact of bacteria during growth phase with xenobiotics. O. anthropi and A. xylosoxidans appeared to be the most adapted to the presence of PCBs (with sufficient membrane adaptation), active under the adverse conditions, and able to survive in the contaminated environment.

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“…The toxicity threshold concentration of phenol against microbial strains is different from a strain to another. This toxicity resulting in cell decay can be attributed at the cellular level, according to Heipieper et al, 1994) to a feasible suggestion that phenolic compounds degrade the cell membrane integrity, reducing the membrane's efficacy as a selective. At the molecular level, dehydrogenase enzymes needed in catalyzing the biological oxidation of organic compounds, are membrane associated (Kewelo et al, 1990and Heipieper et al, 1991.…”

Section: Nutritional and Environmental Factors Affecting Growth And Pmentioning

confidence: 99%

Evaluation of Nutritional and Environmental Conditions for Phenol Degradation by a Lebanese strain of Candida tropicalis

Koubeissi¹,

Yusef²,

Holail³

2017

Int.J.Curr.Microbiol.App.Sci

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Mechanisms of resistance of whole cells to toxic organic solvents

Cited by 450 publications

References 26 publications

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

Alcoholic fermentation of carbon sources in biomass hydrolysates by Saccharomyces cerevisiae: current status

The adaptation responses of bacterial cytoplasmic membrane fluidity in the presence of environmental stress factors — polychlorinated biphenyls and 3-chlorobenzoic acid

Evaluation of Nutritional and Environmental Conditions for Phenol Degradation by a Lebanese strain of Candida tropicalis

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