Mechanisms of regulatory diversity within the p53 transcriptional network

Transcriptional Regulation by P53

“…However, for many genes, such as p21, it is clear that the levels of p53 bound are not the sole determinant of the ensuing transcriptional response (Espinosa et al 2003;Donner et al 2007;Mattia et al 2007;Hill et al 2008b). In fact, it appears that similar levels of bound p53 can direct a differential PIC assembly that is both locus-and stimulus-specific (Espinosa 2008), as depicted in Figure 3. How is this accomplished?…”

p53 Basic C Terminus Regulates p53 Functions through DNA Binding Modulation of Subset of Target Genes

“…An alternative model, a selective context model, proposes that p53 binds all accessible binding sites and that specificity is achieved at subsequent regulatory steps. At least four aspects of the interactions between p53 and its target genes have been suggested to take part in either of these models of p53-dependent cell fate determination: 1) the strength of individual p53 responsive elements, 2) post-translational modifications affecting the p53 protein, and more specifically its CTD, 3) p53 binding partners, and 4) the epigenetic landscape of p53 target genes (55,56). According to the results presented here characterizing a mutant p53 with deletion of the CTD, none of these models are adequate.…”

Interaction between p53 and estradiol pathways in transcriptional responses to chemotherapeutics

“…1,2 Equally important is the "quality" of the response element sequences and the cooperation/interaction with other transcription factors. 1,2 The tumor suppressor p53, which has been described as the "guardian of the genome," controls several biological outcomes that include cell cycle, growth, apoptosis, senescence, angiogenesis and genome stability.…”

“…1,2 Equally important is the "quality" of the response element sequences and the cooperation/interaction with other transcription factors. 1,2 The tumor suppressor p53, which has been described as the "guardian of the genome," controls several biological outcomes that include cell cycle, growth, apoptosis, senescence, angiogenesis and genome stability. 3,4 Also, it can regulate many other cellular processes such as autophagy, energy metabolism, mTOR signaling, immune responses, cell motility/migration and cellcell communication, in part through modulation of several microRNA genes.…”