“…1,2 Equally important is the "quality" of the response element sequences and the cooperation/interaction with other transcription factors. 1,2 The tumor suppressor p53, which has been described as the "guardian of the genome," controls several biological outcomes that include cell cycle, growth, apoptosis, senescence, angiogenesis and genome stability. 3,4 Also, it can regulate many other cellular processes such as autophagy, energy metabolism, mTOR signaling, immune responses, cell motility/migration and cellcell communication, in part through modulation of several microRNA genes.…”