Mechanisms of regeneration of the endothelium at diabetes mellitus

Kuznetsova, H.S.; Kuznetsova, K.S.; Byts, T.M.; Bobryk, L. M.; Кузнецова, О. М.; Гоженко, А. І.

doi:10.31793/1680-1466.2018.23-4.384

Cited by 2 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We previously found that diabetic angiopathy is accompanied by an increase in the level of desquamated endothelial cells (CECs) circulating in the blood, commensurate with its severity. 1,2,3,4,5,6,7 In this study, we set ourselves the goal of analyzing the level of CECs in patients with cardiovascular pathology and their relationship with the level of blood pressure and routine clinical indicators.…”

Section: Introductionmentioning

confidence: 99%

Circulating in the blood desquamated endotheliocytes at the cardiovascular diseases. Preliminary communication

Gozhenko,

Pavlega,

Badiuk

et al. 2024

Qual Sport

View full text Add to dashboard Cite

Introduction and aim. We previously found that diabetic angiopathy is accompanied by an increase in the level of desquamated endothelial cells (CECs) circulating in the blood, commensurate with its severity. In this study, we set ourselves the aim of analyzing the level of CECs in patients with cardiovascular pathology and their relationship with the level of blood pressure and routine clinical indicators. Material and methods. The object of clinical observation were patients with stage II hypertension, who were receiving outpatient treatment. Among them, 23 men (62.3±13.2 ys) and 39 women (65.1±10.6 ys). Concomitant ischemic heart disease was diagnosed in 16 men (70±10%) and 28 women (72±7%). The main subject of the study was blood pressure and the level of CECs. In addition, routine general blood analysis and determined metabolic parameters were performed. Results. Using the method of cluster analysis, the sample was divided into 4 homogeneous groups, different from each other. It was found that in 18 patients of the first cluster, the youngest in the sample, the minimum level of hypertension for the sample occurs against the background of unchanged CECs levels and other registered parameters, instead, it is accompanied by moderate increased creatininemia and a significantly increased rate of erythrocyte sedimentation and a reduced level of hemoglobin and color index. In 18 patients of the second cluster, moderately elevated levels of terminally and markedly changed CECs were found in combination with minimally expressed signs of hyperchromic anemia. In the third cluster (n=16), the levels of terminally and markedly changed CECs are significantly increased in combination with a reduced level of urea and LP index against the background of moderate hyperchromic anemia. Finally, in 10 patients of the fourth cluster, the oldest in the sample, with maximally expressed hypertension, it is accompanied by maximally elevated levels of all three types of СEСs against the background of moderate hyperchromic anemia. Conclusion. Desquamated plasma endothelial cells can be one of the criteria for the severity of hypertonic disease.

show abstract

Section: Introductionmentioning

confidence: 99%

Circulating in the blood desquamated endotheliocytes at the cardiovascular diseases. Preliminary communication

Gozhenko,

Pavlega,

Badiuk

et al. 2024

Qual Sport

View full text Add to dashboard Cite

show abstract

“…Исследования последних лет существенно изменили представления о роли эндотелия сосудов в общем гомеостазе. С тех пор как в 1980 году была открыта способность эндотелия синтезировать оксид азота (NO), стало известно, что эндотелий отвечает за модулирование тонуса сосудов, транспорт веществ в клетки сосудистой стенки, участвует в регуляции поддержания агрегатного состояния крови, проницаемости кровеносных сосудов, ангиогенезе, формировании внеклеточного мат рикса, обеспечивает трофическую и защитную функции по отношению к другим слоям сосудистой стенки и многое другое [5,6].…”

unclassified

Стойкое Снижение Эндотелиальной Десквамации У Пациентов С Сахарным Диабетом

Kuznetsova¹,

Гоженко²,

Kuznetsova³

et al. 2019

Endokr.

Self Cite

View full text Add to dashboard Cite

В статье представлены результаты клинического исследования особенностей повреждения эндотелия у пациентов с сахарным диабетом. Цель работы — определить характер и степень изменения десквамации эндотелия в результате нормализации гликемии и коррекции сопутствующей патологии у пациентов с СД 1-го и 2-го типов. Материал и методы. В исследовании принимали участие 50 пациентов с СД1 и СД2. Интенсивность десквамации эндотелия определяли по модифицированному методу J. Hladovec. Результаты. Исходно уровень эндотелиоцитемии у пациентов с СД составил 2530±694 клеток/мл. Назначенная сахароснижающая терапия ассоциировалась с клинически значимым улучшением контроля гликемии — средний уровень НbА1с снизился с 8,42±0,2% до 7,36±0,3% (p<0,001). Через 3 месяца от начала исследования уровень ЦЭК снизился на 32,57% со средним значением 1706±58,9 клеток/мл (p<0,001). Статистически значимой разницы по уровню эндотелиальной десквамации между пациентами с СД1 и СД2 не было на всех этапах исследования.

show abstract

Mechanisms of regeneration of the endothelium at diabetes mellitus

Cited by 2 publications

References 47 publications

Circulating in the blood desquamated endotheliocytes at the cardiovascular diseases. Preliminary communication

Circulating in the blood desquamated endotheliocytes at the cardiovascular diseases. Preliminary communication

Стойкое Снижение Эндотелиальной Десквамации У Пациентов С Сахарным Диабетом

Contact Info

Product

Resources

About