Mechanisms of platinum-induced peripheral neuropathy in cancer patients

Chubykina, S.V.; Tatarinova, M.Yu.; Avakyan, G.G.

doi:10.17116/jnevro202312307119

Z. nevrol. psikhiatr. im. S.S. Korsakova

2023

DOI: 10.17116/jnevro202312307119

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Mechanisms of platinum-induced peripheral neuropathy in cancer patients

S.V. Chubykina,

M.Yu. Tatarinova,

G.G. Avakyan

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2024

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Cited by 1 publication

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An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Yin,

Ke,

Liang

et al. 2024

Adv Healthcare Materials

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Chemotherapy is the cornerstone of triple‐negative breast cancer. The poor effectiveness and severe neuropathic pain caused by it have a significant impact on the immune system. Studies confirmed that immune cells in the tumor microenvironment (TME), have critical roles in tumor immune regulation and prognosis. In this study, it is revealed that the painless administration of Esketamine, combined with Cisplatin (DDP), can exert an anti‐tumor effect, which is further boosted by the hydrogel delivery system. It is also discovered that Esketamine combined with DDP co‐loaded in Poloxamer Hydrogel (PDEH) induces local immunity by increasing mature Dendritic Cells (mDCs) and activated T cells in PDEH group while the regulatory T cells (Tregs) known as CD4+CD25+FoxP3+decreased significantly. Finally, , CD8+ and CD4+ T cells in the spleen exhibited a significant increase, suggesting a lasting immune impact of PDEH. This study proposes that Esketamine can serve as a painless immune modulator, enhancing an anti‐tumor effect while co‐loaded in poloxamer hydrogel with DDP. Along with improving immune cells in the microenvironment, it can potentially alleviate anxiety and depression. With its outstanding bio‐safety profile, it offers promising new possibilities for painless clinical therapy.

show abstract

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

Yin,

Ke,

Liang

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

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Mechanisms of platinum-induced peripheral neuropathy in cancer patients

Cited by 1 publication

References 42 publications

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

An Immune‐Enhancing Injectable Hydrogel Loaded with Esketamine and DDP Promotes Painless Immunochemotherapy to Inhibit Breast Cancer Growth

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