Mechanisms of platelet-mediated liver regeneration

Lisman, Ton; Porte, Robert J.

doi:10.1182/blood-2016-04-692665

Cited by 65 publications

(55 citation statements)

References 62 publications

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“…More recently, it was demonstrated that intraoperative platelet count and platelet transfusion were associated with faster liver regeneration in living donor transplant recipients . The molecular mechanisms of platelet‐mediated stimulation of liver regeneration are, however, still largely unknown …”

Section: Introductionmentioning

confidence: 99%

Transient von Willebrand factor‐mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

Kirschbaum

Jenne

Veldhuis

et al. 2017

Liver International

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Section: Introductionmentioning

confidence: 99%

Transient von Willebrand factor‐mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

Kirschbaum

Jenne

Veldhuis

et al. 2017

Liver International

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“…The decrease of serotonin in Tph1 knockout mice and inhibition of Htr2a and Htr2b, the receptors of serotonin, both impair the process of liver regeneration. The mechanism of serotonin-mediated liver regeneration is still controversial (Lisman and Porte, 2016). On the one hand, serotonin may promote the mitogenic process of hepatocytes in mice after hepatectomy; on the other hand, the decrease in serotonin influences the platelet activation, while the delayed liver regeneration may be a secondary effect of the impaired platelet activation.…”

Section: Serotonin and Tissue Regenerationmentioning

confidence: 99%

The Role of Serotonin beyond the Central Nervous System during Embryogenesis

Liu

2017

Front. Cell. Neurosci.

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Serotonin, or 5-hydroxytryptamine (5-HT), is a well-known neurotransmitter that plays vital roles in neural activities and social behaviors. Clinically, deficiency of serotonin is linked with many psychiatric disorders. Interestingly, a large proportion of serotonin is also produced outside the central nervous system (CNS). There is increasing evidence demonstrating important roles of serotonin in the peripheral tissues. Here, we will describe the multiple biological functions of serotonin in hematopoietic system, such as development of hematopoietic stem and progenitor cells (HSPCs), differentiation of hematopoietic cells, maintenance of vascular system, and relationship with hematological diseases. The roles of serotonin in inflammatory responses mediated by hematopoietic cells as well as in liver regeneration are also discussed. Our recent understandings of the impact of serotonin on hematopoietic system, immune responses, and tissue regeneration support utilization of serotonin as a potential therapeutic target for the treatment of hematological diseases and organ repair in clinic.

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“…All the mechanisms promoting liver regeneration and involving platelets are not yet very well understood but they certainly play an important role through the release of various mediators like serotonin, hepatocyte growth factor, insulin growth factor, and vascular endothelial growth factor. The last one supports liver regeneration by stimulating neoangiogenesis [22].…”

Section: Infectious Complicationsmentioning

confidence: 99%

Thrombocytopenia in Liver Transplant

Droc¹

2018

Thrombocytopenia

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Thrombocytopenia is a common complication of both chronic liver disease and liver transplantation (LT). The mechanism of thrombocytopenia is multifactorial implicating not only sequestration in the spleen, or in the graft, reduction in the mean platelet survival but also decreased platelet production due to low synthesis of thrombopoietin (TPO) or direct toxicity to the bone marrow. Platelets play a dualistic role in liver transplant, both beneficial and detrimental. The beneficial role of platelets is due to platelet-derived serotonin that is involved in liver regeneration. During surgery for liver transplant, in addition to the preoperative causes for thrombocytopenia, we have other mechanisms that will contribute to further deterioration of the platelets count and function: hemodilution, immunological reactions, and sequestration in the newly transplanted graft. This might result in a life-threatening level of thrombocytes. The concern is when we should treat thrombocytopenia because despite life-saving benefits, transfusion has also been related to complications and platelet transfusion has been identified as an independent risk factor for postoperative complications. Risks related to platelet concentrate administration are allergic reactions, alloimmunization, bacterial sepsis, and transfusion-related acute lung injury (TRALI). Administration of platelets is not indicated if there is no bleeding or immediate bleeding risk. New emerging therapies like thrombopoietin-receptor agonist will furthermore limit the administration of blood products.

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Mechanisms of platelet-mediated liver regeneration

Cited by 65 publications

References 62 publications

Transient von Willebrand factor‐mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

Transient von Willebrand factor‐mediated platelet influx stimulates liver regeneration after partial hepatectomy in mice

The Role of Serotonin beyond the Central Nervous System during Embryogenesis

Thrombocytopenia in Liver Transplant

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