Mechanisms of Physical Fatigue and its Applications in Nutritional Interventions

Ma, Xuan; Chen, Hui; Cao, Lixing; Zhao, Shuang; Zhao, Chong; Yin, Shutao; Hu, Hongbo

doi:10.1021/acs.jafc.1c01251

Cited by 16 publications

(16 citation statements)

References 126 publications

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“…Multiple mechanisms are involved in exercise-induced fatigue, mainly the depletion of energy, metabolite accumulation, oxidative stress, inflammatory response, neurotransmitters secretion disorders, and HPA axis hypofunction (Zhou and Jiang, 2019;Ma et al, 2021). Therefore, rational and effective treatments have been taken into consideration, and the TCMs intervention has been proven to be an effective solution in help in improving exercise endurance and alleviating exercise-induced fatigue.…”

Section: Possible Molecular Mechanisms Of Tcms In Relieving Exercise-...mentioning

confidence: 99%

The use of traditional Chinese medicines in relieving exercise-induced fatigue

Liu

Li²,

Shen³

et al. 2022

Front. Pharmacol.

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Exercise-induced fatigue is a non-pathological fatigue and indicated by a reduction of muscle performance that is caused by excessive physical activity. It seriously affects the daily lives of people, in particular athletes, military personnel, and manual laborers. In recent years, increasing attention has been paid to improving the adverse effect of exercise-induced fatigue on people’s daily activities. Thus, studies and applications of traditional Chinese medicines (TCMs) in relieving exercise-induced fatigue have become the focus because of their good curative effects with fewer side effects. This review aims to document and summarize the critical and comprehensive information about the biological processes of exercise-induced fatigue, and to know the types of TCMs, their active components, and possible molecular mechanisms in alleviating exercise-induced fatigue. The peripheral and central mechanisms that cause exercise-induced fatigue have been summarized. A total of 47 exercise-induced fatigue relief TCMs have been collected, mostly including the types of visceral function regulation and emotional adjustment TCMs. Polysaccharides, terpenes, flavonoids/polyphenols are demonstrated to be the major bioactive components. The underlying molecular mechanisms are mainly related to the improvement of energy metabolism, elimination of excess metabolites, inhibition of oxidative stress and inflammatory response, regulation of HPA axis and neurotransmitters. Although current results are obtained mostly from animal models, the clinic trials are still insufficient, and a very few TCMs have been reported to possess potential hepatotoxicity. These findings still offer great reference value, and the significant efficacy in relieving exercise-induced fatigue is impossible to ignore. This review is expected to give insights into the research and development of new TCMs-derived drugs and health care products in relieving exercise-induced fatigue.

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Section: Possible Molecular Mechanisms Of Tcms In Relieving Exercise-...mentioning

confidence: 99%

The use of traditional Chinese medicines in relieving exercise-induced fatigue

Liu

Li²,

Shen³

et al. 2022

Front. Pharmacol.

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“…In this study, the familiarization consisted only of 2 × 15 min blocks of the LIST. The effectiveness of New Zealand blackcurrant extract was more apparent in the later stages of the LIST (i.e., stage 4 and 5), suggesting an ergogenic effect while being in a fatigued state ( 22 ) and experiencing oxidative stress-induced fatigue ( 23 ). In addition, New Zealand blackcurrant extract (210 mg anthocyanins·day −1 for 7 days) had the ergogenic effect of reduced slowing of sprint time in the running-based anaerobic sprint test (6 × 35-m maximal sprints interspersed by 10-s passive recovery periods) later in the protocol (i.e., sprint 5) ( 24 ).…”

Section: Anthocyanins and Exercise Performancementioning

confidence: 99%

Anthocyanin-Rich Supplementation: Emerging Evidence of Strong Potential for Sport and Exercise Nutrition

Willems

Blacker

2022

Front. Nutr.

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Dark-colored fruits, especially berries, have abundant presence of the polyphenol anthocyanin which have been show to provide health benefits. Studies with the berry blackcurrant have provided notable observations with application for athletes and physically active individuals. Alterations in exercise-induced substrate oxidation, exercise performance of repeated high-intensity running and cycling time-trial and cardiovascular function at rest and during exercise were observed with intake of New Zealand blackcurrant. The dynamic plasma bioavailability of the blackcurrant anthocyanins and the anthocyanin-derived metabolites must have changed cell function to provide meaningful in-vivo physiological effects. This perspective will reflect on the research studies for obtaining the applied in-vivo effects by intake of anthocyanin-rich supplementation, the issue of individual responses, and the emerging strong potential of anthocyanins for sport and exercise nutrition. Future work with repeated intake of known amount and type of anthocyanins, gut microbiota handling of anthocyanins, and coinciding measurements of plasma anthocyanin and anthocyanin-derived metabolites and in-vivo cell function will be required to inform our understanding for the unique potential of anthocyanins as a nutritional ergogenic aid for delivering meaningful effects for a wide range of athletes and physically active individuals.

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“…Nowadays, nutrition intervention has been regarded as a practical therapy for fatigue management and has demonstrated promising efficacy in human and mouse studies. 6,9 Therefore, there is considerable interest in the search for naturally occurring substances because of their effective ability to resist fatigue and low adverse reactions.…”

Section: ■ Introductionmentioning

confidence: 99%

Polygonatum cyrtonema Hua Polysaccharide Alleviates Fatigue by Modulating Osteocalcin-Mediated Crosstalk between Bones and Muscles

Jiang

Chen

et al. 2023

J. Agric. Food Chem.

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Osteocalcin was reported to regulate muscle energy metabolism, thus fighting fatigue during exercise. The current work aimed to investigate the anti-fatigue effect and the underlying mechanism of a homogeneous polysaccharide (PCPY-1) from Polgonatum cyrtonema after structure characterization. In the exhaustive swimming mouse model and the co-culture system of BMSCs/C2C12 cells, PCPY-1 significantly stimulated BMSC differentiation into osteoblasts as determined by ALP activity, matrix mineralization, and the protein expressions of osteogenic markers BMP-2, phosphor-Smad1, RUNX2, and osteocalcin. Meanwhile, PCPY-1 remarkably enhanced myoblast energy metabolism by upregulating osteocalcin release and GPRC6A protein expression; the phosphorylation levels of CREB and HSL; the mRNA levels of GLUT4, CD36, FATP1, and CPT1B; and ATP production in vitro and in vivo. Accordingly, PCPY-1 exhibited good anti-fatigue capacity in mice as confirmed by fatigue-related indicators. Our findings indicated PCPY-1 could enhance osteocalcin-mediated communication between bones and muscles, which was conducive to muscle energy metabolism and ATP generation, thus alleviating fatigue in exhausted swimming mice.

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Mechanisms of Physical Fatigue and its Applications in Nutritional Interventions

Cited by 16 publications

References 126 publications

The use of traditional Chinese medicines in relieving exercise-induced fatigue

The use of traditional Chinese medicines in relieving exercise-induced fatigue

Anthocyanin-Rich Supplementation: Emerging Evidence of Strong Potential for Sport and Exercise Nutrition

Polygonatum cyrtonema Hua Polysaccharide Alleviates Fatigue by Modulating Osteocalcin-Mediated Crosstalk between Bones and Muscles

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