Mechanisms of photoinduced electron transfer reactions of lappaconitine with aromatic amino acids. Time-resolved CIDNP study

Polyakov, Nikolay E.; Khan, Vladimir K.; Taraban, Marc B.; Leshina, Tatyana V.; Luzina, O. A.; Salakhutdinov, N. F.; Толстиков, Г. А.

doi:10.1039/b416133e

Cited by 22 publications

(51 citation statements)

References 24 publications

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“…The second hypothesis is the influence of complexation on metabolism rate of the drug at the binding site of corresponding receptor [34]. It has been described in [60] the potential model of drug-receptor interaction where chemical transformations of the drug were a key step in the dissociation of the drug-receptor complex. This model was developed by the example of the calcium channel blocker nifedipine [60].…”

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

“…It has been described in [60] the potential model of drug-receptor interaction where chemical transformations of the drug were a key step in the dissociation of the drug-receptor complex. This model was developed by the example of the calcium channel blocker nifedipine [60].…”

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

“…Since detailed computational [60]. The investigation of the model reaction -photoinduced interaction of NF with Tyr in the presence and absence of GA in solution by using CIDNP method has shown that the inclusion of NF into the complex with GA significantly decrease the rate of single electron transfer [34] (Detailed description is done in chapter 4.2).…”

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

“…Chemically Induced Dynamic Nuclear Polarization (CIDNP) technique was used to establish the detailed molecular mechanism of the interaction of NF with amino acid residues [60]. The model reaction in solution was initiated by UV irradiation.…”

Section: Interaction Of Nifedipine-glycyrrhizin Complex With Amino Acmentioning

confidence: 99%

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Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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Supramolecular drug delivery systems (DDS) are widely used in pharmacology during last decades for designing new preparations with improved properties. Most of fundamental and applied research in this field has been devoted to the inclusion complexes with cyclodextrins (CD), which are assumed to possess protective properties and to decrease the hydrophobic behavior of the included molecules. At present a new generation of DDS has been developing. Novel DDS are focused simultaneously on several purposes, including improved bioavailability and stability of drugs, targeted drug delivery, and enhanced activity. One of the compounds that appear to be promising is glycyrrhizic acid (or glycyrrhizin). A number of experimental facts of high therapeutic activity of glycyrrhizin conjugates have been published, but no understanding "how it works" was presented. This manuscript will highlight our attempts to answer this question using physicochemical approach, and also outline the challenges and future opportunities for medical applications of glycyrrhizin conjugates.

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Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

Section: Complex Of Glycyrrhizin With Nifedipinementioning

confidence: 99%

Section: Interaction Of Nifedipine-glycyrrhizin Complex With Amino Acmentioning

confidence: 99%

See 2 more Smart Citations

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Polyakov

Leshina²

2011

TOPROCJ

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“…Фармакологически перспективными являются комплексы ГК с нестероидными противовоспалительными средствами [10], простагландинами [11], антиаритмиком аллапинином (гидробромид дитерпенового алкалоида лаппаконитина) [12,13], антидепрессантом прозаком [14], противоопухолевыми препаратами 5-фторурацилом, фторафуром, рубомицином [15], противомикробными препаратами левомицетином, сульфапиридезином, салазодиметоксином, сульгином, резорцином [16].…”

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Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid

Tg¹,

Mv²,

Ao³

et al. 2010

BIOMED KHIM

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A new water-soluble form of the calcium blocker nifedipine (NF) with glycyrrhizic acid (GA) (with molecular ratio 1:4) has been obtained by mechanochemical synthesis. Its pharmacological advantages in comparison with nifedipine were determined. An effective dose of nifedipine in complex reduced to 10 times as compared to its therapeutic dose while high antihypertensive activity preservation and pleiotropic antiarhythmic activity enhancement. This new antihypertensive and antiarhythmic agent (complex of NF:GA = 1:4) is chemically stable and safe for parenteral administration.

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Photoinduced Interaction of Atorvastatin with Acetophenone

et al. 2015

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The one of the most often prescribed preparation in the world, atorvastatin (ATR), lipid-lowering agent and antioxidant, is used for the prevention and treatment of atherosclerosis. At that the nature of its antioxidant activity is still unknown. This work presents the first example of the elementary mechanisms of ATR red-ox reactions, including the single electron transfer and the interaction with short-lived ketyl radicals. ATR reactivity has been investigated by means of the method of time-resolved chemically induced dynamic nuclear polarization (TR-CIDNP), nuclear magnetic resonance spectroscopy, ultraviolet spectroscopy, highperformance liquid chromatography, mass spectrometry and quantum chemical (DFT) calculations. To study the interaction of ATR with ketyl radicals in the solution acetophenone photolysis was used as a model reaction. It was shown that carbon atoms, belonging to the secondary alcohol groups of the dihydroxyheptane acid anion, are the reaction centers of ATR molecule in reactions with ketyl radicals. Because all statins have this fragment, one can expect that other statins could react with free radicals by this route. Thus, the proposed mechanism might be the one among several channels providing statins antioxidant activity.

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Mechanisms of photoinduced electron transfer reactions of lappaconitine with aromatic amino acids. Time-resolved CIDNP study

Cited by 22 publications

References 24 publications

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Glycyrrhizic Acid as a Novel Drug Delivery Vector: Synergy of Drug Transport and Efficacy

Improvement of pharmacological values of the nifedipine by means of mechanochemical complexation with glycyrrhizic acid

Photoinduced Interaction of Atorvastatin with Acetophenone

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