Mechanisms of osteoarthritis in the knee: MR imaging appearance

Shapiro, Lauren M.; McWalter, Emily J.; Son, Min-Sun; Levenston, Marc E.; Hargreaves, Brian A.; Gold, Garry E.

doi:10.1002/jmri.24562

Cited by 20 publications

(21 citation statements)

References 87 publications

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“…As the purpose of group 2 was to include individuals with possible early OA, any potential participants in group 2 with MR evidence of established OA -as defined for the purposes of this study by full thickness cartilage defects or BMLs -were excluded. We did not include ligament damage or meniscal pathology in our exclusion criteria as these are considered as predisposing factors for OA rather than features of established OA as such [29]. One potential group 2 subject was excluded due to a full thickness cartilage defect.…”

Section: Clinical Mr Analysismentioning

confidence: 99%

MRI texture analysis of subchondral bone at the tibial plateau

et al. 2015

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2 ABSTRACT PurposeTo determine the feasibility of MRI texture analysis as a method of quantifying subchondral bone architecture in knee osteoarthritis (OA). MethodsAsymptomatic subjects aged 20-30 (group 1, n=10), symptomatic patients aged 40-50 (group 2, n=10) and patients scheduled for knee replacement aged 55-85 (group 3, n=10) underwent high spatial resolution T1 weighted coronal 3T knee MRI.Regions of interest were created in the medial (MT) and lateral (LT) tibial subchondral bone from which 20 texture parameters were calculated. T2 mapping of the tibial cartilage was performed in groups 1 & 2. Mean parameter values were compared between groups using ANOVA. Linear discriminant analysis (LDA) was used to evaluate the ability of texture analysis to classify subjects correctly. ResultsSignificant differences in 18/20 and 12/20 subchondral bone texture parameters were demonstrated between groups at the MT and LT respectively. There was no significant difference in mean MT or LT cartilage T2 values between group 1 and group 2.LDA demonstrated subject classification accuracy of 97% (95% CI 91-100%). ConclusionMRI texture analysis of tibial subchondral bone may allow detection of alteration in subchondral bone architecture in OA. This has potential applications in understanding OA pathogenesis and assessing response to treatment.

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Section: Clinical Mr Analysismentioning

confidence: 99%

MRI texture analysis of subchondral bone at the tibial plateau

et al. 2015

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“…MR imaging has a role in the assessment of knee joint but it is expensive [7][8][9][10]. Ultrasound is becoming more popular in the evaluation of different musculoskeletal abnormalities such as different rheumatic disease, soft tissue lesions, and joints [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound of knee osteoarthritis: interobserver agreement and correlation with Western Ontario and McMaster Universities Osteoarthritis

Razek

El-Basyouni

2015

Clin Rheumatol

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The aim of this work was to assess the reproducibility of ultrasound findings of knee osteoarthritis and to correlate ultrasound findings with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Prospective study was conducted upon 80 patients (56 F, 24 M; mean age 57 years) with primary osteoarthritis of knee joint. All patients underwent clinical assessment with calculation of WOMAC and high-resolution ultrasound of the knee joint. The ultrasound images were analyzed for cartilage thinning, osteophytes, synovial effusion, synovial proliferation, popliteal cyst, and meniscal protrusion. Image analysis was performed by two readers and linear regression analysis was used to determine association of ultrasound findings with WOMAC. There was excellent inter-observer agreement of both readers for cartilage thinning (k = 0.99, P = 0.001), osteophytes (k = 0.94, P = 0.001), synovial effusion (k = 0.98, P = 0.001), synovial thickening (k = 0.96, P = 0.001), popliteal cyst (k = 1.00, P = 0.001), and meniscal protrusion (k = 0.86, P = 0.001). There was significant association of WOMAC with cartilage changes (t = 3.406, 3.302, P = 0.001), osteophytes (t = 3.841, 3.006, P = 0.001), and synovial effusion (t = 4.140 and 2.787, P = 0.05) of both readers. We concluded that ultrasound is a reproducible method for assessment of knee osteoarthritis and well correlated with WOMAC.

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“…Osteoarthritis, also known as degenerative arthritis, is a very common and significant disease characterized by decreases in proteoglycan (PG) and collagen fibers in the articular cartilage (1,2). Although many cartilage regeneration treatment methods have been developed due to advances in molecular biology and stem cell research (2,3), cartilage damage is irreversible, and the only treatment method for severely damaged articular cartilage is arthroplasty with an artificial joint.…”

Section: Introductionmentioning

confidence: 99%

“…Although many cartilage regeneration treatment methods have been developed due to advances in molecular biology and stem cell research (2,3), cartilage damage is irreversible, and the only treatment method for severely damaged articular cartilage is arthroplasty with an artificial joint. Thus, early detection of degeneration is important to enable early therapeutic intervention, reduced disability, and improve patient quality of life (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Proteoglycan and Type II Collagen on T1ρ Relaxation Time of Articular Cartilage

Choi

Yoo

Hong

et al. 2015

J Korean Soc Radiol

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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose:To evaluate the effects of proteoglycan and type II collagen within articular cartilage on T1ρ relaxation time of articular cartilage. Materials and Methods: This study was exempted by the institutional and animal review boards, and informed consent was not required. Twelve porcine patellae were assigned to three groups of control, trypsin-treated (proteoglycan-degraded), or collagenase-treated (collagen-degraded). The T1ρ images were obtained with a 3 tesla magnetic resonance imaging scanner with a single loop coil. Statistical differences were detected by analysis of variance to evaluate the effects of the enzyme on T1ρ relaxation time. Safranin-O was used to stain proteoglycan in the articular cartilage and immunohistochemical staining was performed for type II collagen. Results: Mean T1ρ values of the control, trypsin-treated, and collagenase-treated groups were 37.72 ± 5.82, 57.53 ± 8.24, and 45.08 ± 5.31 msec, respectively (p < 0.001). Histology confirmed a loss of proteoglycan and type II collagen in the trypsin-and collagenase-treated groups. Conclusion: Degradation of proteoglycans and collagen fibers in the articular cartilage increased the articular cartilage T1ρ value.

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Mechanisms of osteoarthritis in the knee: MR imaging appearance

Cited by 20 publications

References 87 publications

MRI texture analysis of subchondral bone at the tibial plateau

MRI texture analysis of subchondral bone at the tibial plateau

Ultrasound of knee osteoarthritis: interobserver agreement and correlation with Western Ontario and McMaster Universities Osteoarthritis

The Effects of Proteoglycan and Type II Collagen on T1ρ Relaxation Time of Articular Cartilage

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