Mechanisms of oesophageal mucosal defence

Sarosiek, Jerzy; McCallum, Richard W.

doi:10.1053/bega.2000.0119

Cited by 55 publications

(78 citation statements)

References 35 publications

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“…The esophagus is important organ [16] for passage of food from the mouth to the stomach. The present animals (Rabbit -herbivorous needs this mucous to increase the viscosity of the esophagus which is important allowing the passage of large food.…”

Section: Discussionmentioning

confidence: 99%

Comparative Histological Studies of the Esophagus Wall of Oryctolagus cuniculus Rabbit Adult, Young and Lactating Using Light Microscope

Selim¹,

Hazaa²,

Goda³

2017

J Cytol Histol

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Background: As the different parts of the alimentary canal, the esophagus is an important part of it, because it facilitate the passage of food material to the stomach. The purpose of this study was to compare the structure of the esophageal wall of rabbit before weaning (lactating) and after weaning (young and adult) to determine the structural changes that accompany the changes of the feeding pattern from lactating to adult.

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Section: Discussionmentioning

confidence: 99%

Comparative Histological Studies of the Esophagus Wall of Oryctolagus cuniculus Rabbit Adult, Young and Lactating Using Light Microscope

Selim¹,

Hazaa²,

Goda³

2017

J Cytol Histol

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“…This study adds TFF3 to the list of protective peptides, such as EGF and transforming growth factor α (TGFα), secreted by the esophageal submucosal glands (Sarosiek and McCallum 2000). However, all attempts have failed to detect TFF1 or TFF2 biosynthesis in these glands (not illustrated).…”

Section: Discussionmentioning

confidence: 99%

Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axis

et al. 2007

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TFF3 (trefoil factor family 3), which is a major secretory product of the gastric antrum and the intestine, but which is nearly absent in the gastric corpus, plays a key role in the maintenance of mucosal integrity. Here, we have systematically investigated TFF3 expression in the esophagus and gastric cardia by the use of reverse transcription/polymerase chain reaction (RT-PCR) analysis and immunohistochemistry. Synthesis of TFF3, but not TFF1 or TFF2, is detectable in esophageal submucosal glands. The stratified squamous epithelium is devoid of TFF synthesis. Prominent TFF3 expression starts at the Z-line with a sharply decreasing gradient toward the cardia. Immunohistochemistry has localized TFF3 to surface mucous cells of the proximal cardia. TFF3 distribution differs characteristically from that of TFF1 (secreted primarily by superficial surface mucous cells), whereas TFF3, together with the mucin MUC5AC, is also found in deeper lying cells toward the isthmus. This is the first report of TFF3 as a typical secretory peptide of esophageal submucosal glands and gastric cardia. The different expression patterns of TFF3 and TFF1 in the cardia suggest a stepwise maturation of surface mucous cells from TFF3/MUC5AC-positive cells close to the isthmus to TFF1/TFF3/MUC5AC-positive cells at the pit. The gradient of TFF3 expression along the gastric rostro-caudal axis defines two types of gastric pit cells: those secreting TFF3 in the cardia and the antrum and those nearly devoid of TFF3 synthesis in the corpus. This indicates the special requirement, particularly of the esophagogastric junction, for TFF3-triggered protection and repair.

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“…Such a study, however, should be conducted in the future with simultaneous assessment of esophageal acid exposure time during 24-h pH monitoring. This insight could be of great pathogenetic value, as the integrity of the esophageal mucosa depends upon equilibrium between aggressive factors and protective mechanisms [1,5,11,12].…”

Section: Discussionmentioning

confidence: 99%

“…In patients with gastroesophageal reflux disease (GERD), especially accompanied by endoscopic erosions, so-called reflux esophagitis (RE), esophageal epithelium is injured by acid and pepsin within the gastroesophageal reflux (GER) [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Significant Increase of Esophageal Mucin Secretion in Patients with Reflux Esophagitis After Healing with Rabeprazole: Its Esophagoprotective Potential

et al. 2008

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Esophageal mucin secretion in patients with reflux esophagitis (RE) is significantly impaired. Rabeprazole augments gastric mucin secretion. We have studied, therefore, the effect of rabeprazole on esophageal mucin secretion in patients with RE. The study was conducted in 15 patients with RE treated with rabeprazole (20 mg QD) for 8 weeks. Esophageal secretions were collected during consecutive infusions of initial NaCl, HCl/Pepsin (HCl/P), and a final NaCl, using a specially designed esophageal catheter, before and after therapy. Mucin was measured using standard methodology. After rabeprazole administration esophageal mucin concentration as well as secretion increased during perfusion with initial saline (P < 0.01), HCl/P (P < 0.02), and concluding saline (P < 0.001). Stimulation of esophageal mucin secretion by rabeprazole may indicate that the mechanisms governing its secretion are similar to those implicated in gastric mucin output. Enhancement of esophageal mucin secretion by rabeprazole may translate into esophagoprotective potential in patients with reflux esophagitis.

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Mechanisms of oesophageal mucosal defence

Cited by 55 publications

References 35 publications

Comparative Histological Studies of the Esophagus Wall of Oryctolagus cuniculus Rabbit Adult, Young and Lactating Using Light Microscope

Comparative Histological Studies of the Esophagus Wall of Oryctolagus cuniculus Rabbit Adult, Young and Lactating Using Light Microscope

Localization of TFF3 peptide in human esophageal submucosal glands and gastric cardia: differentiation of two types of gastric pit cells along the rostro-caudal axis

Significant Increase of Esophageal Mucin Secretion in Patients with Reflux Esophagitis After Healing with Rabeprazole: Its Esophagoprotective Potential

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