Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients

Gattorno, Marco; Rubartelli, Anna

doi:10.1007/978-3-0348-0148-5_12

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2015

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“…Although inflammasomes are well known to participate in intracellular responses to pathogens and stress, their roles in the innate response caused by inflammation and in autoimmune diseases, metabolic disorders and cancer are receiving increasing attention [23][24][25][26] . The role of estrogens in inflammation has been widely studied, but there are few studies that have specifically addressed the biological effects of CFA in combination with estrogen to evaluate the transcriptional activation of the inflammasomes.…”

Section: Discussionmentioning

confidence: 99%