Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis

Yang, Xiaofan; Ma, Yayun; Chen, Xin; Zhu, Jingjing; Xue, Wenlong; Ning, Ke

doi:10.1016/j.lfs.2023.121867

Cited by 7 publications

(2 citation statements)

References 199 publications

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“…The effects of the CETP-expressing BM on reducing aortic neutrophils may have resulted from the reduction in TNF-α (and likely other pro-inflammatory cytokines and chemokines) in the lesion microenvironment. The reduced neutrophils together with reduced TNF-α may not be a coincidence, since a vast body of research links TNF-α and neutrophil recruitment to inflammation sites [41][42][43][44]. TNF-α promotes recruitment, activation, and prolongs the lifespan of neutrophils at sites of inflammation such as atherosclerotic injuries [43].…”

Section: Discussionmentioning

confidence: 99%

CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

Rentz,

Dorighello,

dos Santos

et al. 2023

Biomolecules

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CETP activity reduces plasma HDL-cholesterol concentrations, a correlate of an increased risk of atherosclerotic events. However, our recent findings suggest that CETP expression in macrophages promotes an intracellular antioxidant state, reduces free cholesterol accumulation and phagocytosis, and attenuates pro-inflammatory gene expression. To determine whether CETP expression in macrophages affects atherosclerosis development, we transplanted bone marrow from transgenic mice expressing simian CETP or non-expressing littermates into hypercholesterolemic LDL-receptor-deficient mice. The CETP expression did not change the lipid-stained lesion areas but decreased the macrophage content (CD68), neutrophil accumulation (LY6G), and TNF-α aorta content of young male transplanted mice and decreased LY6G, TNF-α, iNOS, and nitrotyrosine (3-NT) in aged female transplanted mice. These findings suggest that CETP expression in bone-marrow-derived cells reduces the inflammatory features of atherosclerosis. These novel mechanistic observations may help to explain the failure of CETP inhibitors in reducing atherosclerotic events in humans.

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Section: Discussionmentioning

confidence: 99%

CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

Rentz,

Dorighello,

dos Santos

et al. 2023

Biomolecules

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show abstract

“…Among these cardiovascular diseases, atherosclerotic cerebrovascular disease (ACVD), which is primarily characterized by carotid atherosclerosis (CAS), is the main cause ( 4 , 5 ). Carotid atherosclerosis evolves as a consequence of endothelial damage ( 6 ) and is characterized by the accumulation of atherosclerotic plaques predominantly composed of low-density lipoprotein cholesterol on the carotid artery’s inner walls ( 7 , 8 ). Over time, these plaques progressively induce arterial stenosis, with the principal site of this process being the bifurcation of the internal and external carotid arteries ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Metabolomics and network pharmacology exploration of the effects of bile acids on carotid atherosclerosis and potential underlying mechanisms

Cheng,

Zhang,

et al. 2024

Front. Endocrinol.

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BackgroundBile acids (BAs), products of gut microbiota metabolism, have long been implicated in atherosclerotic disease pathogenesis. Characterizing the serum bile acid profile and exploring its potential role in carotid atherosclerosis (CAS) development are crucial tasks.MethodsIn this study, we recruited 73 patients with CAS as the disease group and 77 healthy individuals as the control group. We systematically measured the serum concentrations of 15 bile acids using ultrahigh-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Multivariate logistic regression and least absolute shrinkage and selection operator (LASSO) regression were applied to analyze the impact of bile acids on the disease and select the key BAs. The possible molecular mechanism was elucidated by network pharmacology.Results(1) The BA profile of patients with CAS significantly differed. (2) Multifactorial logistic regression analysis identified elevated levels of GCDCA (OR: 1.01, P < 0.001), DCA (OR: 1.01, P = 0.005), and TDCA (OR: 1.05, P = 0.002) as independent risk factors for CAS development. Conversely, GCA (OR: 0.99, P = 0.020), LCA (OR: 0.83, P = 0.002), and GUDCA (OR: 0.99, P = 0.003) were associated with protective effects against the disease. GCA, DCA, LCA, and TDCA were identified as the four key BAs. (3) TNF, FXR, GPBAR1, ESR1 and ACE were predicted to be targets of BAs against AS. These four BAs potentially impact AS progression by triggering signaling pathways, including cAMP, PPAR, and PI3K-AKT pathways, via their targets.ConclusionThis study offers valuable insights into potential therapeutic strategies for atherosclerosis that target bile acids.

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Light-emitting diode-induced ellagic acid production in Drosera tokaiensis inhibits advanced glycation end-product formation

Tominaga,

Katogi,

Hoshi

et al. 2023

Biocatalysis and Agricultural Biotechnology

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Mechanisms of neutrophil extracellular trap in chronic inflammation of endothelium in atherosclerosis

Cited by 7 publications

References 199 publications

CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

CETP Expression in Bone-Marrow-Derived Cells Reduces the Inflammatory Features of Atherosclerosis in Hypercholesterolemic Mice

Metabolomics and network pharmacology exploration of the effects of bile acids on carotid atherosclerosis and potential underlying mechanisms

Light-emitting diode-induced ellagic acid production in Drosera tokaiensis inhibits advanced glycation end-product formation

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