Mechanisms of Nephrosclerosis Development in Children With Vesicoureteral Reflux

Морозова, О.Л.; Леонидовна, Морозова Ольга; Litvitsky, P.F.; Францевич, Литвицкий Петр; Morozov, D A; Анатольевич, Морозов Дмитрий; Maltseva, Larisa D.; Дмитриевна, Мальцева Лариса

doi:10.15690/vramn1021

Cited by 2 publications

(2 citation statements)

References 1 publication

(34 reference statements)

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“…После чего мф, поглощая апоптотическую клетку, подвергают ее обработке и экспрессируют на своей поверхности чужеродные антигены в сочетании с молекулами главного комплекса гистосовместимости [31]. Этот процесс сопровождается активной продукцией провоспалительных цитокинов -IFN-γ, интерлейкина (IL) 1β, IL6, IL12, IL15, IL18, IL23, IL27, TNF, хемокинов -CXCL9, CXCL10, CXCL11, а также экспрессией поверхностных маркеров -CD40, CD80, CD86 [32,39]. Происходит увеличение выработки оксида азота, активных форм кислорода, высвобождаются протеолитические ферменты, в т.ч.…”

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“…По мере прогрессирования патологического процесса и развития фиброза наблюдается постепенная трансформация мф фенотипа М1 в М2, в ткани рекрутируются T-хелперы 2 и регуляторные T-клетки, cекретирующие IL4, IL10 [40]. Мф М2 типа, в свою очередь, секретируют цитокины CCLК7, CCL22, CCL24, трансформирующий фактор роста-β (TGF-β), тромбоцитарный фактор роста (PDGF), фактор роста фибробластов 2 (FGF-2) и другие профибротические цитокины, и представляют на своей поверхности такие поверхностные маркеры, как CD163, стабилин-1 [28,36,39,41,42]. TGF-β, воздействуя на фибробласты, усиливает их способность продуцировать компоненты внеклеточного матрикса [43].…”

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Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction

Kercheva

Рябов

2021

Russ J Cardiol

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Cardiorenal syndrome (CRS) in patients with acute myocardial infarction (MI) underlies the development and progression of renal and heart failure. Along with the well-known mechanisms of CRS development based on reninangiotensin system activation, kidney-heart macrophage axis may be one of the key cellular components of CRS. Continuous sympathetic stimulation of collecting duct system cells under ischemia activates the macrophage link of the kidneys, which contributes to cardiac macrophages' polarization and leads to the development of adaptive myocardial hypertrophy and fibrosis. This review article summarizes current data on interaction of macrophages in the kidney-heart axis, which can be considered as the cellular basis for CRS development in patients with MI. The translation of experimental data on the participation of innate immune system on CRS model in humans will make it possible to find new ways to prevent and suppress acute kidney injury in patients with MI.

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Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction

Kercheva

Рябов

2021

Russ J Cardiol

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Vesicoureteral reflux as a manifestation of CAKUT-syndrome in children: the problem of late diagnosis

Макарова

Самойлова

Melnikova

et al. 2021

Nefrologiâ (St.-Peterbg.)

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CAKUT-syndrome includes combined congenital abnormalities of the kidneys and urinary tract and is a complex problem in pediatrics, requiring an interdisciplinary approach of doctors of various specialties. One of the most severe manifestations of CAKUT-syndrome is vesicoureteral reflux, which is often the main manifestation of a congenital abnormality of the kidneys and urinary tract. Structural and urodynamic disorders in the organs of the urinary system in vesicoureteral reflux can lead to the formation of reflux nephropathy and chronic kidney disease. Low-symptom clinical manifestations of reflux nephropathy make it difficult to diagnose it early. Vesicoureteral reflux leads to intrarenal reflux, repeated attacks of pyelonephritis and sclerosis of the renal tissue, which in 25-60 % of cases causes end-stage chronic renal failure due to vesicoureteral reflux. Given the absence of specific pathognomonic clinical manifestations of reflux nephropathy, laboratory indicators are of fundamental importance in the diagnosis-levels of albuminuria, leukocyturia, urinary sediment fermenturia, urine osmolarity, daily urinary excretion of β2 – microglobulin and a wide arsenal of methods for diagnosing reflux nephropathy and scarring of the renal parenchyma: ultrasound with dopplerography of the renal blood flow, magnetic resonance imaging and computed tomography, radioisotope scanning. The imperfection of instrumental methods for visualizing the initial stages of kidney fibrosis dictates the need to develop alternative, more sensitive methods for early diagnosis of reflux nephropathy. One of the directions of this search is molecular diagnostics, which allows you to detect possible damage to the renal tissue at the subcellular level long before the clinical manifestations of pathology, personify nephroprotective therapy and prevention of reflux nephropathy. The article presents clinical observations from our own practice of late diagnosis of reflux nephropathy, in which renal pathology was first detected at stages 5 and 3 of chronic kidney disease in two boys aged 10 and 16 years, respectively, who were on inpatient treatment in the Nephrology Department of the Children's Republican clinical hospital.

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Mechanisms of Nephrosclerosis Development in Children With Vesicoureteral Reflux

Cited by 2 publications

References 1 publication

Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction

Role of macrophages in cardiorenal syndrome development in patients with myocardial infarction

Vesicoureteral reflux as a manifestation of CAKUT-syndrome in children: the problem of late diagnosis

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