Mechanisms of motility changes during acute intestinal obstruction in the dog

Abstract

We investigated the effects of autonomic drugs and the role of intestinal contents on the motility changes that occur during acute obstruction. Myoelectric activity was recorded from seven electrodes spaced at 3-cm intervals along the midjejunum of nine conscious dogs. Another animal had electrodes evenly placed throughout the small bowel. Obstruction was created by inflation of an intraluminal balloon. Systemic arterial blood pressure and pulse rate were monitored. Initially, motor activity of the small intestine increased proximal to an acute intestinal obstruction and decreased distally. Recordings from the entire small intestine revealed that these effects occurred almost immediately in the region of the obstruction but not at more distant sites. Within 2-3 h, however, proximal hypermotility had extended to the duodenum and distal inhibition had progressed to the terminal ileum. Diversion of intestinal contents without obstruction reduced myoelectric activity distal to the site of drainage. However, reinfusion of chyme distal to the site of obstruction failed to restore inhibited motor activity to control levels. Atropine sulfate (50 micrograms/kg) decreased and neostigmine (5 micrograms X kg-1 X min-1) potentiated the hyperactivity proximal to the obstruction, but neither agent significantly affected the distal inhibition. Phentolamine (1 mg/kg) and propranolol (1 mg/kg) had no effect on proximal or distal motor activity during obstruction; these were doses that blocked cardiovascular responses to adrenergic agonists. These results suggest that changes in luminal contents and in nervous activity both contribute to the intestinal motility changes that accompany obstruction.(ABSTRACT TRUNCATED AT 250 WORDS)

Mechano‐transcription of COX‐2 is a common response to lumen dilation of the rat gastrointestinal tract

“…tumors and diverticulitis. In laboratory animals, lumen dilation has been reproduced by external application of a silicon band [7-9], or by inflation of an intraluminal balloon [6, 35]. In the present study, we found that no matter the method, lumen dilation leads to gene expression of COX-2 in the alimentary tract.…”

Prophylactic and therapeutic benefits of COX-2 inhibitor on motility dysfunction in bowel obstruction: roles of PGE2 and EP receptors

“…Bowel obstruction leads to altered motility function with suppression in smooth muscle contractility (5,43,53). Motility dysfunction is responsible for symptoms such as vomiting, abdominal distension, pain, and constipation (34,46), and may lead to intestinal failure (13,47). The molecular mechanisms underlying these changes are not known.…”

Relation between flow-pressure-diameter studies in experimental stenosis of rabbit and human small bowel.

“…Seven segments were of terminal ileum resected at the time of a right hemicolectomy performed for tumours (5) or ulcerative colitis (2); five were macroscopically healthy looking areas of gut located between stenoses in patients with Crohn's disease. The loops were 5 to 8 cm long and in them we assessed a 1 cm long stenosis perfused with normal saline.…”