Mechanisms of meiotic drive in symmetric and asymmetric meiosis

Kruger, Alyssa N.; Mueller, Jacob L.

doi:10.1007/s00018-020-03735-0

Cited by 22 publications

(18 citation statements)

References 92 publications

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“…Overall, our results indicate that in these hybrids, male meiosis does not contribute significantly, or not at all, to genome dominance and that it has to be female meiosis responsible for the shift toward roylei genome. This is in line with Courret et al (2019) and Kruger and Mueller (2021) , who hypothesized that meiotic drivers function exclusively in the male or female germline, but not both. However, we cannot completely rule out other mechanisms including differences in the gamete viability and preferential fertilization.…”

Section: Discussionsupporting

confidence: 87%

“…Male meiosis is symmetric and all the four products participate equally to successive generation. However, meiotic drivers increase the chance of the sperm cells carrying them to fertilize the eggs and, thus, violate the random transmission of sperm cells with or without the driver ( Kruger and Mueller, 2021 ). Male meiotic drivers seem to benefit themselves and confer negative effects on the counterpart (from the other parental genome in the case of interspecific hybrids) such as reduced motility of sperms, differences in the pollinating rate of pollen grains, and failure to develop to maturity.…”

Section: Discussionmentioning

confidence: 99%

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Genome Dominance in Allium Hybrids (A. cepa × A. roylei)

et al. 2022

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Genome dominance is a phenomenon in wide hybrids when one of the parental genomes becomes “dominant,” while the other genome turns to be “submissive.” This dominance may express itself in several ways including homoeologous gene expression bias and modified epigenetic regulation. Moreover, some wide hybrids display unequal retention of parental chromosomes in successive generations. This may hamper employment of wide hybridization in practical breeding due to the potential elimination of introgressed segments from progeny. In onion breeding, Allium roylei (A. roylei) Stearn has been frequently used as a source of resistance to downy mildew for cultivars of bulb onion, Allium cepa (A. cepa) L. This study demonstrates that in A. cepa × A. roylei hybrids, chromosomes of A. cepa are frequently substituted by those of A. roylei and in just one generation, the genomic constitution shifts from 8 A. cepa + 8 A. roylei chromosomes in the F1 generation to the average of 6.7 A. cepa + 9.3 A. roylei chromosomes in the F2 generation. Screening of the backcross generation A. cepa × (A. cepa × A. roylei) revealed that this shift does not appear during male meiosis, which is perfectly regular and results with balanced segregation of parental chromosomes, which are equally transmitted to the next generation. This indicates that female meiotic drive is the key factor underlying A. roylei genome dominance. Single nucleotide polymorphism (SNP) genotyping further suggested that the drive has different strength across the genome, with some chromosome segments displaying Mendelian segregation, while others exhibiting statistically significant deviation from it.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Genome Dominance in Allium Hybrids (A. cepa × A. roylei)

et al. 2022

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“…The potential functional consequences of this sequence diversity for the dynamics of centromeric chromatin and kinetochore assembly remain to be elucidated. Importantly, even subtle perturbations to kinetochore assembly or stability could have downstream impacts on the fidelity of chromosome segregation and propensity for centromere drive (Henikoff et al 2001; Malik and Henikoff 2001; Pardo-Manuel de Villena and Sapienza 2001; Talbert et al 2004; Kursel and Malik 2018; Kruger and Mueller 2021; Kumon et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Strain level centromere variation influences CENP-A association dynamics and centromere function

Arora

Sullivan

Dumont

2022

Preprint

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Centromeres are rapidly evolving chromatin domains that fulfill essential roles in chromosome segregation. Rapid centromere sequence evolution imposes strong selection for compensatory changes in centromere-associated kinetochore proteins, leading to striking co-evolutionary trends across species. However, it remains unknown whether within species centromere sequence diversity leads to functional differences in kinetochore protein association. House mice (Mus musculus) exhibit significant variation in centromere satellite array size and sequence heterogeneity, but the amino acid sequence of CENP-A, a centromere-specific histone variant that specifies centromere identity, is conserved. We hypothesize that centromere satellite sequence variation leads to differences in the localization of CENP-A among house mice, with potential consequences for meiotic drive and genome stability. Using CENP-A chromatin immunoprecipitation with a customized k-mer based, reference-blind bioinformatic analysis strategy, we compare the CENP-A sequence association landscape in four diverse inbred mouse strains (C57BL/6J, CAST/EiJ, LEWES/EiJ, and PWK/PhJ). We uncover significant strain-level diversity in CENP-A associated sequences, with more closely related strains exhibiting more similar CENP-A association profiles. LEWES/EiJ and CAST/EiJ show mild association of CENP-A with the pericentromeric satellite repeat, countering the prevailing notion that functional centromere size is solely determined by the size of the minor satellite array. Strain-specific CENP-A association profiles are enriched for unique suites of transcription factor motifs, hinting at strain differences in centromere transcription. Given the importance of centromere-CENP-A association and centromere transcription for both kinetochore assembly and chromosome segregation fidelity, our findings suggest a potential mechanism for centromere-mediated variation in genome stability among inbred mouse strains.

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“…For example, sex chromosomes often display a phenomenon referred to as meiotic drive in which either the male or female determining chromosome is preferentially transmitted to offspring. [12][13][14] Similarly, balanced translocations, which are infertile in the transheterozygous state, were proposed by Chris Curtis in the 1960s as a means for spreading favorable genetic traits into a population. [15] The identification and molecular characterization of specific selfish genetic elements such as HEGs led mathematical modelers such as pioneer Austin Burt and colleagues to develop a modern framework for engineering HEG-based gene-drive systems to introduce F I G U R E 2 Gene-drive systems.…”

Section: Introductionmentioning

confidence: 99%

Active genetics comes alive

Bier

2022

BioEssays

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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based "active genetic" elements developed in 2015 bypassed the fundamental rules of traditional genetics. Inherited in a super-Mendelian fashion, such selfish genetic entities offered a variety of potential applications including: gene-drives to disseminate gene cassettes carrying desired traits throughout insect populations to control disease vectors or pest species, allelic drives biasing inheritance of preferred allelic variants, neutralizing genetic elements to delete and replace or to halt the spread of gene-drives, splitdrives with the core constituent Cas9 endonuclease and guide RNA (gRNA) components inserted at separate genomic locations to accelerate assembly of complex arrays of genetic traits or to gain genetic entry into novel organisms (vertebrates, plants, bacteria), and interhomolog based copying systems in somatic cells to develop tools for treating inherited or infectious diseases. Here, we summarize the substantial advances that have been made on all of these fronts and look forward to the next phase of this rapidly expanding and impactful field.

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Mechanisms of meiotic drive in symmetric and asymmetric meiosis

Cited by 22 publications

References 92 publications

Genome Dominance in Allium Hybrids (A. cepa × A. roylei)

Genome Dominance in Allium Hybrids (A. cepa × A. roylei)

Strain level centromere variation influences CENP-A association dynamics and centromere function

Active genetics comes alive

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